Evidence map›Paper›PMID 32952508›Full record

ArticleSaudi journal of medicine & medical sciences

Association of Four Missense SNPs with Preeclampsia in Saudi Women.

Nada Mohammed Aljuaid, Ebtesam Ibrahim Muharram, Nouf Nasser Loqtum, Reem Mohammed Al-Amoudi, Hadiah Bassam AlMahdi, Mohammed Assem Salama, Babajan Banaganapalli, Noor Ahmad Shaik, Ramu Elango, Nabeel Salem Bondagji

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Saudi journal of medicine & medical sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Nada Mohammed AljuaidDepartment of Biological Sciences, Faculty of Science, University of Jeddah, Jeddah, Saudi Arabia.
Ebtesam Ibrahim MuharramDepartment of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
Nouf Nasser LoqtumDepartment of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
Reem Mohammed Al-AmoudiDepartment of Obstetrics and Gynecology, Maternity and Children's Hospital, Jeddah, Saudi Arabia.
Hadiah Bassam AlMahdiDepartment of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
Mohammed Assem SalamaDepartment of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
Babajan BanaganapalliPrincess Al-Jawhara Al-Brahim Center of Excellence in Research of Hereditary Disorders, King Abdulaziz University, Jeddah, Saudi Arabia.
Noor Ahmad ShaikPrincess Al-Jawhara Al-Brahim Center of Excellence in Research of Hereditary Disorders, King Abdulaziz University, Jeddah, Saudi Arabia.
Ramu ElangoPrincess Al-Jawhara Al-Brahim Center of Excellence in Research of Hereditary Disorders, King Abdulaziz University, Jeddah, Saudi Arabia.
Nabeel Salem BondagjiPrincess Al-Jawhara Al-Brahim Center of Excellence in Research of Hereditary Disorders, King Abdulaziz University, Jeddah, Saudi Arabia.
King Abdulaziz University · SAMaternity and Children's Hospital · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe objective of this study was to investigate the association of rs1051740, rs2234922 (in MATERIALS AND

methodsThis case-control study recruited 233 Saudi women (94 preeclampsia cases and 139 healthy controls) who visited the Gynecology and Obstetrics Departments of two hospitals in Jeddah, Saudi Arabia, for routine postpregnancy clinical follow-ups. All the women underwent thorough clinical and biochemical investigations conducted according to the standard clinical guidelines. Genotyping of the study participants was done using real-time polymerase chain reaction-based TaqMan allelic discrimination assay. The strength of the association between genetic variants and disease development was assessed using chi-square, odds ratio, 95% confidence interval and multifactor dimensionality reduction tests.

resultThe minor alleles "G" in rs268 (

conclusionThis study found that none of the studied genetic variants (neither the single SNP nor the SNP-SNP interactions) explain the development of preeclampsia in the Saudi population. These findings not only underscore the disease heterogeneity but also highlight the need to develop population-specific diagnostic genetic biomarkers for preeclampsia.

Indexed as

EPHX1 geneF5 genelipoprotein lipase genepolymorphismpreeclampsiasingle-nucleotide polymorphism

Identifiers

PMID32952508
PMCPMC7485656
OpenAlexW3081294362

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.