ArticleOrganic process research & development2020
Improved scale-up synthesis and purification of clinical asthma candidate MIDD0301.
Article in Organic process research & development, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Development of Novel Pegylated Imidazobenzodiazepines Targeting α5 GABAA Receptors for Anxiety: A Comparative Prodrug and Metabolite Study.ACS chemical neuroscience · 2026Article
- Structure-Activity Relationship Study on Ligands Activating the Voltage-Gated Potassium Channel KArchiv der Pharmazie · 2026Article
- A strategy for the controllable generation of organic superbases from benchtop-stable salts.Chemical science · 2024Article
- Design, Synthesis, and Biological Evaluation of Novel Spiro Imidazobenzodiazepines to Identify Improved Inhaled Bronchodilators.Journal of medicinal chemistry · 2023Article
- Synthesis and Receptor Binding Studies of α5 GABAMolecules (Basel, Switzerland) · 2023Article
- Development of Inhaled GABAACS pharmacology & translational science · 2022Article
- Identification and Quantification of MIDD0301 Metabolites.Current drug metabolism · 2021Article
- Nebulized MIDD0301 Reduces Airway Hyperresponsiveness in Moderate and Severe Murine Asthma Models.ACS pharmacology & translational science · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
We report an improved and scalable synthesis of MIDD0301, a positive GABA
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.