ArticleActa Cardiologica Sinica2020
Association between Low-Grade Inflammation and Left Ventricular Diastolic Dysfunction in Patients with Metabolic Syndrome and Hyperuricemia.
Article in Acta Cardiologica Sinica, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 9 citations in OpenAlex.
- Left ventricular hypertrophy detection using electrocardiographic signal.Scientific reports · 2023Article
- Serum Uric Acid Is a Weak Independent Predictor of Overall Survival in Older Adults.Journal of clinical medicine · 2021Article
- Neutrophil-to-lymphocyte ratio associated with an increased risk of mortality in patients with critical limb ischemia.PloS one · 2021Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
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Abstract
backgroundHyperuricemia (HUA) induces inflammation and insulin resistance and is reportedly associated with left ventricular hypertrophy (LVH) and possibly with left ventricular diastolic dysfunction (LVDD).
objectivesTo investigate associations among HUA, inflammation, and insulin resistance with LVDD.
methodsWe enrolled patients with metabolic syndrome (MetS) between August 1, 2017, and December 31, 2017. All participants underwent fasting blood tests and transthoracic echocardiography. HUA was defined as an serum uric acid level ≥ 7 mg/dl in men or ≥ 6 mg/dl in women. MetS was defined as at least three of the following Taiwanese criteria: central obesity, prehypertension, fasting glucose impairment, hypertriglyceridemia, and lower values of high-density lipoprotein cholesterol. LVDD was defined according to contemporary guidelines.
resultsThe study included 63 patients (60% male) with a mean age of 53 ± 14 years and body mass index (BMI) of 29.4 ± 4.0 kg/m
conclusionsThe association between HUA and LVDD partially reflected a low-grade inflammation due to elevated TNF-α rather than increased insulin resistance in MetS patients.
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