ArticleThe Journal of biological chemistry2020
Mass spectrometry characterization of light chain fragmentation sites in cardiac AL amyloidosis: insights into the timing of proteolysis.
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Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
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Who cites it
29 citing papers in PubMed, 70 citations in OpenAlex.
- Small Molecule Stabilization of Diverse Amyloidogenic Immunoglobulin Light Chains Revealed by Hydrogen-Deuterium Exchange Mass Spectrometry.Journal of molecular biology · 2026Article
- Polymorphic IGLV6-57 AL amyloid fibrils and features of a shared folding pathway.Nature communications · 2026Article
- Cryo-EM of Cardiac AL-224L Amyloid Reveals Shared Structural Motifs and Mutation-induced Differences in λ6 Light Chain Fibrils.Journal of molecular biology · 2026Article
- Biopsy-resolved cryo-EM structures of amyloid fibrils provide molecular insights into AL amyloidosis.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Small molecule stabilization of diverse amyloidogenic immunoglobulin light chains revealed by hydrogen-deuterium exchange mass spectrometry.bioRxiv : the preprint server for biology · 2026Article
- In vitro and in vivo disease models of cardiac amyloidosis: progress, pitfalls, and potential.Cardiovascular research · 2025Review
- Charting the structure-sequence landscape of light chain amyloids.Bioinformatics (Oxford, England) · 2025Article
- A mouse model of cardiac immunoglobulin light chain amyloidosis reveals insights into tissue accumulation and toxicity of amyloid fibrils.Nature communications · 2025Article
- Article
- Conformational Differences in the Light Chain Constant Domain of Immunoglobulin G and Free Light Chain May Influence Proteolysis in AL Amyloidosis.Journal of molecular biology · 2024Article
- Predicting Structural Consequences of Antibody Light Chain N-Glycosylation in AL Amyloidosis.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Helical superstructures between amyloid and collagen in cardiac fibrils from a patient with AL amyloidosis.Nature communications · 2024Article
- Biophysical characterization of human-cell-expressed, full-length κI O18/O8, AL-09, λ6a, and Wil immunoglobulin light chains.Biochimica et biophysica acta. Proteins and proteomics · 2024Article
- Kinetic evidence for multiple aggregation pathways in antibody light chain variable domains.Protein science : a publication of the Protein Society · 2024Article
- Producing amyloid fibrils in vitro: A tool for studying AL amyloidosis.Biochemistry and biophysics reports · 2023Article
- Diagnostic Challenges and Solutions in Systemic Amyloidosis.International journal of molecular sciences · 2023Review
- Widespread amyloidogenicity potential of multiple myeloma patient-derived immunoglobulin light chains.BMC biology · 2023Article
- Proteomics-Based Analysis and Diagnosis of Formalin-Fixed Paraffin-Embedded Amyloidosis Samples.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Cryo-EM structure of ex vivo fibrils associated with extreme AA amyloidosis prevalence in a cat shelter.Nature communications · 2022Article
- An N-glycosylation hotspot in immunoglobulin κ light chains is associated with AL amyloidosis.Leukemia · 2022Article
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 2 countries.
Francesca LavatelliAmyloidosis Research and Treatment Center, Fondazione IRCCS Policlinico San Matteo and University of Pavia, Pavia, Italy. Electronic address: francesca.lavatelli@unipv.it.
Giulia MazziniAmyloidosis Research and Treatment Center, Fondazione IRCCS Policlinico San Matteo and University of Pavia, Pavia, Italy.
Stefano RicagnoDepartment of Biosciences, Università degli Studi di Milano, Milan, Italy.
Federica IavaroneDepartment of Basic Biotechnological Sciences, Intensivological and Perioperative Clinics, Faculty of Medicine, Università Cattolica del Sacro Cuore, Rome, Italy; Clinical Chemistry, Biochemistry and Molecular Biology Clinic, Fondazione Policlinico Agostino Gemelli IRCCS, Rome, Italy.
Paola RognoniAmyloidosis Research and Treatment Center, Fondazione IRCCS Policlinico San Matteo and University of Pavia, Pavia, Italy.
Paolo MilaniAmyloidosis Research and Treatment Center, Fondazione IRCCS Policlinico San Matteo and University of Pavia, Pavia, Italy.
Mario NuvoloneAmyloidosis Research and Treatment Center, Fondazione IRCCS Policlinico San Matteo and University of Pavia, Pavia, Italy.
Paolo SwuecDepartment of Biosciences, Università degli Studi di Milano, Milan, Italy; Cryo-Electron Microscopy Facility, Human Technopole, Milan, Italy.
Serena CaminitoAmyloidosis Research and Treatment Center, Fondazione IRCCS Policlinico San Matteo and University of Pavia, Pavia, Italy.
Masayoshi TasakiDepartment of Morphological and Physiological Sciences, Graduate School of Health Sciences, Kumamoto University, Kumamoto, Japan; Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Antonio Chaves-SanjuanDepartment of Biosciences, Università degli Studi di Milano, Milan, Italy.
Andrea UrbaniDepartment of Basic Biotechnological Sciences, Intensivological and Perioperative Clinics, Faculty of Medicine, Università Cattolica del Sacro Cuore, Rome, Italy; Clinical Chemistry, Biochemistry and Molecular Biology Clinic, Fondazione Policlinico Agostino Gemelli IRCCS, Rome, Italy.
Giampaolo MerliniAmyloidosis Research and Treatment Center, Fondazione IRCCS Policlinico San Matteo and University of Pavia, Pavia, Italy.
Giovanni PalladiniAmyloidosis Research and Treatment Center, Fondazione IRCCS Policlinico San Matteo and University of Pavia, Pavia, Italy.
University of Pavia · ITUniversity of Milan · ITUniversità Cattolica del Sacro Cuore · ITKumamoto Health Science University · JP
Funding
No grant is acknowledged in the PubMed record.
Abstract
Amyloid fibrils are polymeric structures originating from aggregation of misfolded proteins.
Indexed as
Amino Acid SequenceAmyloidChromatography, High Pressure LiquidElectrophoresis, Gel, Two-DimensionalHumansImmunoglobulin Light-chain AmyloidosisImmunoglobulin Light ChainsMyocardiumPeptidesProtein Structure, SecondaryProtein Structure, TertiaryProteolysisTandem Mass SpectrometryAmyloidImmunoglobulin Light ChainsPeptidesamyloidamyloid fibrilscardiomyopathyfibrilmass spectrometry (MS)protein aggregationprotein conformationprotein structureproteolysisproteomicsstructural biology
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