Evidence map›Paper›PMID 32951947›Full record

ArticleTrends in genetics : TIG2020

Base Editing Landscape Extends to Perform Transversion Mutation.

Kutubuddin A Molla, Yiping Qi, Subhasis Karmakar, Mirza J Baig

Abstract readComment
PubMed Publisher
In one paragraph

Article in Trends in genetics : TIG, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Prime editing in hematopoietic stem cells-FromFrontiers in genome editing · 2023
    Review
  8. Review
  9. Reconstructed glycosylase base editors GBE2.0 with enhanced C-to-G base editing efficiency and purity.Molecular therapy : the journal of the American Society of Gene Therapy · 2022
    Article
  10. Review
  11. Efficient gene editing through an intronic selection marker in cells.Cellular and molecular life sciences : CMLS · 2022
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Kutubuddin A MollaIndian Council of Agricultural Research (ICAR)-National Rice Research Institute (NRRI), Cuttack-753006, India. Electronic address: kutubuddin.molla@icar.gov.in.
Yiping QiDepartment of Plant Science and Landscape Architecture, University of Maryland, College Park, MD 20742, USA; Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, MD 20850, USA.
Subhasis KarmakarIndian Council of Agricultural Research (ICAR)-National Rice Research Institute (NRRI), Cuttack-753006, India.
Mirza J BaigIndian Council of Agricultural Research (ICAR)-National Rice Research Institute (NRRI), Cuttack-753006, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Base editors have drawn considerable academic and industrial attention in recent years because of their ability to alter single DNA bases with precision. However, the existing cytosine and adenine base editors can only install transition mutations. Three recent studies (Kurt et al.,Zhao et al., and Chen et al.) expand the base editing toolbox by developing cytosine transversion base editors.

Indexed as

CRISPR-Cas SystemsGene EditingAdenineCytosineMutationAdenineCytosineagriculturebase editingCRISPR/CasC-to-G editingpoint mutationtherapeuticstransversion base editor

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.