ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2020
Multi-system physiological dysregulation and ageing in a subsistence population.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Review
- Oxytocin varies across the life course in a sex-specific way in a human subsistence population.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Contemporary small-scale subsistence populations offer unique insights into human musculoskeletal health and aging.Science advances · 2024Review
- Physiological Dysregulation Proceeds and Predicts Health Outcomes Similarly in Chinese and Western Populations.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Age-related physiological dysregulation progresses slowly in semi-free-ranging chimpanzees.Evolution, medicine, and public health · 2024Article
- Review
- mHealth system (ATOPE+) to support exercise prescription in breast cancer survivors: a reliability and validity, cross-sectional observational study (ATOPE study).Scientific reports · 2022Observational
- An objective metric of individual health and aging for population surveys.Population health metrics · 2022Article
- Article
- A holistic approach to predicting diabetes risk via biomarkers.EBioMedicine · 2021Article
- Urinary neopterin of wild chimpanzees indicates that cell-mediated immune activity varies by age, sex, and female reproductive status.Scientific reports · 2021Article
- Evidence from two cohorts for the frailty syndrome as an emergent state of parallel dysregulation in multiple physiological systems.Biogerontology · 2021Article
- Robust Physiological Metrics From Sparsely Sampled Networks.Frontiers in physiology · 2021Review
- Insights from evolutionarily relevant models for human ageing.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Humans have the longest post-reproductive lifespans and lowest rates of actuarial ageing among primates. Understanding the links between slow actuarial ageing and physiological change is critical for improving the human 'healthspan'. Physiological dysregulation may be a key feature of ageing in industrialized populations with high burdens of chronic 'diseases of civilization', but little is known about age trajectories of physiological condition in subsistence populations with limited access to public health infrastructure. To better characterize human physiological dysregulation, we examined age trajectories of 40 biomarkers spanning the immune (
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.