ArticleJournal of enzyme inhibition and medicinal chemistry2020
Characterisation of naturally occurring isothiocyanates as glutathione reductase inhibitors.
Article in Journal of enzyme inhibition and medicinal chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 17 citations in OpenAlex.
- Organosulfur compounds as dual-action agents: a critical review of antimicrobial and immunomodulatory potentials, and translational barriers.Frontiers in pharmacology · 2026Review
- Exploring the antimicrobial properties of synthetic tetrahydro-2RSC advances · 2025Article
- Spatial covariance reveals isothiocyanate natural products adjust redox stress to restore function in alpha-1-antitrypsin deficiency.Cell reports. Medicine · 2025Article
- Characterization of naphthoquinones as inhibitors of glutathione reductase and inducers of intracellular oxidative stress.Redox report : communications in free radical research · 2024Article
- Antimalarial Activity of Aqueous Extracts of Nasturtium (Molecules (Basel, Switzerland) · 2024Article
- Kinetic properties of glucose 6-phosphate dehydrogenase and inhibition effects of several metal ions on enzymatic activity in vitro and cells.Scientific reports · 2024Article
- Naturally Derived Phenethyl Isothiocyanate Modulates Induction of Oxidative Stress via ItsAntioxidants (Basel, Switzerland) · 2024Article
- Benzyl isothiocyanate improves the prognosis ofFrontiers in microbiology · 2023Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
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Abstract
Glutathione reductase (GR), an essential antioxidant enzyme against oxidative stress, has become an attractive drug target for the development of anticancer and antimalarial drugs. In this regard, we evaluated the naturally occurring isothiocyanates as promising GR inhibitors and elucidated the mechanism of action. It was found that benzyl isothiocyanate (BITC) and phenethyl isothiocyanate (PEITC) inhibited yeast GR (yGR) and human GR (hGR) in a time- and concentration-dependent manner. The
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