Evidence map›Paper›PMID 32951454›Full record

ArticleCancer control : journal of the Moffitt Cancer Center

Is It Possible to Establish a Tumor-Suppressive Microenvironment With Glycine and Valine Supplement?

Shanshan An, Sirui Yan, Ying Zhang, Huan Xu, Tao Gan, Qiuyun Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer control : journal of the Moffitt Cancer Center. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 14 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Shanshan AnSchool of Life Sciences, 26469Sun Yat-sen University, Guangzhou, China.
Sirui YanSchool of Life Sciences, 26469Sun Yat-sen University, Guangzhou, China.
Ying Zhang214164Guangzhou Center for Disease Control and Prevention, Guangzhou, China.
Huan XuSchool of Electronic Information and Automation, 326768Guilin University of Aerospace Technology, Guilin, Guangxi, China.
Tao GanSchool of Basic Medicine, 74554Gannan Medical University, Jiangxi, China.
Qiuyun LiuSchool of Life Sciences, 26469Sun Yat-sen University, Guangzhou, China.ORCID https://orcid.org/0000-0001-5533-0128
Sun Yat-sen University · CNGannan Medical University · CNGuangzhou Center for Disease Control and Prevention · CNGuilin University of Aerospace Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A tumorigenic microenvironment can give rise to neoplasm. A shift from this condition to a tumor-suppressive microenvironment is of significant benefit to susceptible individuals. The carbonyl groups of glycine and valine have long bond lengths, consequently generating potent affinities to divalent cations such as calcium. We hypothesize that the formation of insoluble and rigid calcium oxalate augmented by glycine and valine counteracts strong acids such as HCl chemically, thus reducing cancer risks. The anticancer effects of the 2 amino acids can be explained from a chemical and biochemical perspective. A tumor-suppressive microenvironment could be established via the modification of the proteome without genome editing at the DNA level.

Indexed as

Dietary SupplementsCalcium OxalateGlycineHumansNeoplasmsTumor MicroenvironmentValineCalcium OxalateGlycineValinecalciumglycinetumorigenic microenvironmenttumor-suppressive microenvironmentvaline

Identifiers

PMID32951454
PMCPMC7791438
OpenAlexW3087179146

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.