Evidence map›Paper›PMID 32951453›Full record

ArticleCancer control : journal of the Moffitt Cancer Center

Prognostic Significance of ALDH1, Bmi1, and OCT4 Expression in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma.

Roopa S Rao, Lizbeth Raju K, Dominic Augustine, Shankargouda Patil

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer control : journal of the Moffitt Cancer Center. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.

  1. Pooled it
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  13. The role of OCT4 and CD44 in lower lip carcinogenesis.Oral and maxillofacial surgery · 2025
    Article
  14. Metabolic biomarker in oral squamous cell carcinoma - a comprehensive review.GMS Interdisciplinary plastic and reconstructive surgery DGPW · 2025
    Review
  15. CSCScientific reports · 2024
    Article
  16. Cancer Stem Cells from Definition to Detection and Targeted Drugs.International journal of molecular sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Roopa S RaoDepartment of Oral Pathology and Microbiology, Faculty of Dental Sciences, 410981M.S. Ramaiah University of Applied Sciences, India.
Lizbeth Raju KDepartment of Oral Pathology and Microbiology, Faculty of Dental Sciences, 410981M.S. Ramaiah University of Applied Sciences, India.
Dominic AugustineDepartment of Oral Pathology and Microbiology, Faculty of Dental Sciences, 410981M.S. Ramaiah University of Applied Sciences, India.
Shankargouda PatilDepartment of Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Jazan University, Saudi Arabia.ORCID https://orcid.org/0000-0001-7246-5497
M S Ramaiah University of Applied Sciences · INJazan University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIncreasing evidence suggests the involvement of cancer stem cells (CSCs) in both oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC). Among the various CSC markers, aldehyde dehydrogenase (ALDH) 1, B cell-specific Moloney murine leukaemia virus integration site 1 (Bmi1), and octamer-binding protein 4 (OCT4) have been noted to increase in OSCC. The aim of the study was to analyze ALDH1, Bmi1, and OCT4 expression in OED and OSCC with clinicopathologic correlation and survival analysis.

methodsA total of 40 cases each of OED and OSCC were retrieved from departmental archives. Expression of ALDH1, Bmi1, and OCT4 was analyzed using immunohistochemistry and was correlated with clinicopathological parameters. A follow-up ranging from 6 to 52 months was considered for Kaplan-Meier survival analysis. The log-rank test was performed to analyze significant difference in survival rates.

resultsThe expression levels of ALDH1, Bmi1, and OCT4 increased significantly from OED through OSCC (

conclusionALDH1 and OCT4 could be used as individual prognostic markers for assessing prognosis. ALDH1, Bmi1, and OCT4 could be used as a collective panel of markers to enable surgeons in predicting the prognosis of patients and thereby carry out prompt follow-up for such cases.

Indexed as

AdultAgedAged, 80 and overAldehyde Dehydrogenase 1 FamilyBiomarkers, TumorCarcinoma, Squamous CellFemaleFollow-Up StudiesHumansLymphatic MetastasisMaleMiddle AgedMouth NeoplasmsOctamer Transcription Factor-3Polycomb Repressive Complex 1Precancerous ConditionsAldehyde Dehydrogenase 1 FamilyALDH1A1 protein, humanBiomarkers, TumorBMI1 protein, humanOctamer Transcription Factor-3Polycomb Repressive Complex 1POU5F1 protein, humanRetinal Dehydrogenasealdehyde dehydrogenase 1Bmi1 proteinmouth neoplasmsneoplastic stem cellsPOU5F1 proteinsurvival analysis

Identifiers

PMID32951453
PMCPMC7791458
OpenAlexW3087600504

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.