Evidence map›Paper›PMID 32951306›Full record

ArticleAging cell2020

Autophagy-Sirt3 axis decelerates hematopoietic aging.

Yixuan Fang, Ni An, Lingjiang Zhu, Yue Gu, Jiawei Qian, Gaoyue Jiang, Ruijin Zhao, Wen Wei, Li Xu, Gaochuan Zhang and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 31 citations in OpenAlex.

  1. Trial
  2. Article
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  5. Article
  6. Review
  7. Regulation of Stem Cell Function by NADPhysiology (Bethesda, Md.) · 2025
    Review
  8. Review
  9. Review
  10. Review
  11. Roles of SIRT3 in aging and aging-related diseases.International journal of biological sciences · 2025
    Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. NADOxidative medicine and cellular longevity · 2023
    Review
  17. Fountain of youth-Targeting autophagy in aging.Frontiers in aging neuroscience · 2023
    Review
  18. Ginsenosides on stem cells fate specification-a novel perspective.Frontiers in cell and developmental biology · 2023
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Yixuan FangHematology Center of Cyrus Tang Medical Institute, Jiangsu Institute of Hematology, Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, National Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital, Soochow University School of Medicine, Suzhou, China.
Ni AnHematology Center of Cyrus Tang Medical Institute, Jiangsu Institute of Hematology, Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, National Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital, Soochow University School of Medicine, Suzhou, China.
Lingjiang ZhuHematology Center of Cyrus Tang Medical Institute, Jiangsu Institute of Hematology, Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, National Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital, Soochow University School of Medicine, Suzhou, China.
Yue GuHematology Center of Cyrus Tang Medical Institute, Jiangsu Institute of Hematology, Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, National Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital, Soochow University School of Medicine, Suzhou, China.
Jiawei QianHematology Center of Cyrus Tang Medical Institute, Jiangsu Institute of Hematology, Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, National Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital, Soochow University School of Medicine, Suzhou, China.
Gaoyue JiangHematology Center of Cyrus Tang Medical Institute, Jiangsu Institute of Hematology, Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, National Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital, Soochow University School of Medicine, Suzhou, China.
Ruijin ZhaoHematology Center of Cyrus Tang Medical Institute, Jiangsu Institute of Hematology, Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, National Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital, Soochow University School of Medicine, Suzhou, China.
Wen WeiHematology Center of Cyrus Tang Medical Institute, Jiangsu Institute of Hematology, Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, National Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital, Soochow University School of Medicine, Suzhou, China.
Li XuHematology Center of Cyrus Tang Medical Institute, Jiangsu Institute of Hematology, Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, National Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital, Soochow University School of Medicine, Suzhou, China.
Gaochuan ZhangSchool of Biology and Basic Medical Sciences, Soochow University, Suzhou, China.
Xingyun YaoSchool of Biology and Basic Medical Sciences, Soochow University, Suzhou, China.
Na YuanHematology Center of Cyrus Tang Medical Institute, Jiangsu Institute of Hematology, Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, National Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital, Soochow University School of Medicine, Suzhou, China.
Suping ZhangHematology Center of Cyrus Tang Medical Institute, Jiangsu Institute of Hematology, Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, National Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital, Soochow University School of Medicine, Suzhou, China.
Yun ZhaoHematology Center of Cyrus Tang Medical Institute, Jiangsu Institute of Hematology, Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, National Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital, Soochow University School of Medicine, Suzhou, China.
Jianrong WangHematology Center of Cyrus Tang Medical Institute, Jiangsu Institute of Hematology, Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, National Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital, Soochow University School of Medicine, Suzhou, China.ORCID 0000-0001-8180-5174
Suzhou University of Science and Technology · CNSoochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autophagy suppresses mitochondrial metabolism to preserve hematopoietic stem cells (HSCs) in mice. However, the mechanism by which autophagy regulates hematopoietic aging, in particular in humans, has largely been unexplored. Here, we demonstrate that reduction of autophagy in both hematopoietic cells and their stem cells is associated with aged hematopoiesis in human population. Mechanistically, autophagy delays hematopoietic aging by activating the downstream expression of Sirt3, a key mitochondrial protein capable of rejuvenating blood. Sirt3 is the most abundant Sirtuin family member in HSC-enriched population, though it declines as the capacity for autophagy deteriorates with aging. Activation of autophagy upregulates Sirt3 in wild-type mice, whereas in autophagy-defective mice, Sirt3 expression is crippled in the entire hematopoietic hierarchy, but forced expression of Sirt3 in HSC-enriched cells reduces oxidative stress and prevents accelerated hematopoietic aging from autophagy defect. Importantly, the upregulation of Sirt3 by manipulation of autophagy is validated in human HSC-enriched cells. Thus, our results identify an autophagy-Sirt3 axis in regulating hematopoietic aging and suggest a possible interventional solution to human blood rejuvenation via activation of the axis.

Indexed as

AgingAnimalsAutophagyHematopoietic Stem CellsHumansMiceSirtuin 3SIRT3 protein, humanSirt3 protein, mouseSirtuin 3

Identifiers

PMID32951306
PMCPMC7576273
OpenAlexW3087403821

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.