Trial reportJournal of clinical hypertension (Greenwich, Conn.)2020
Effect of vitamin D supplementation versus placebo on essential hypertension in patients with vitamin D deficiency: a double-blind randomized clinical trial.
Trial report in Journal of clinical hypertension (Greenwich, Conn.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 4 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Does vitamin D supplementation modulate metabolic risk factors of cardiovascular disease? A systematic review and meta-analysis of clinical trials.Asia Pacific journal of clinical nutrition · 2026Pooled it
- Effect of vitamin D supplementation on blood lipids in patients with metabolic syndrome: a meta-analysis.PeerJ · 2026Pooled it
- Calcium, magnesium, and vitamin D supplementations as complementary therapy for hypertensive patients: a systematic review and meta-analysis.BMC complementary medicine and therapies · 2025Pooled it
- Effect of vitamin BBMJ open · 2024Pooled it
- The effect of pregnancy vitamin D supplementation on maternal blood pressure: real-world data analysis within the MAVIDOS randomised placebo-controlled trial.Archives of gynecology and obstetrics · 2025Trial
- Effect of vitamin D supplementation versus placebo on essential hypertension in patients with vitamin D deficiency: a double-blind randomized clinical trial.Journal of clinical hypertension (Greenwich, Conn.) · 2020Trial
- Association Between Vitamin D Deficiency and Cardiovascular Disease Risk Factors in the MENA Population: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
- Vitamin D and Chronic Disorders: A Review of Metabolic and Cardiovascular Diseases.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Vitamin D and hypertension in the elderly; closer to implementation!American heart journal plus : cardiology research and practice · 2025Article
- Review
- Blood Pressure Decreases in Overweight Elderly Individuals on Vitamin D: A Randomized Trial.Journal of the Endocrine Society · 2024Article
- Vitamin D and the Risk of Developing Hypertension in the SUN Project: A Prospective Cohort Study.Nutrients · 2024Article
- Vitamin D and hypertension: Is there any significant relation?Chronic diseases and translational medicine · 2024Article
- Correlation between vitamin D levels and blood pressure in elderly hypertensive patients with osteoporosis.Frontiers in medicine · 2024Article
- Recent Advances in Association Between Vitamin D Levels and Cardiovascular Disorders.Current hypertension reports · 2023Review
- Review
- Latest Knowledge on the Role of Vitamin D in Hypertension.International journal of molecular sciences · 2023Review
- Is Vitamin D Supplementation an Effective Treatment for Hypertension?Current hypertension reports · 2022Review
- The contribution of avoidable factors in doubling or halving the odds of hypertension.PloS one · 2022Article
- Association between vitamin D and cardiovascular health: Myth or Fact? A narrative review of the evidence.Women's health (London, England)Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Findings from randomized trials addressing the effect of vitamin D supplementation and blood pressure are inconsistent and have been the subject of recent debate. This study aimed to assess the effect of vitamin D supplementation on primary hypertension. This double-blind randomized clinical trial was conducted on patients aged 26-84 years with essential hypertension from March 2017 to April 2019. Patients with vitamin D insufficiency (serum vitamin D levels 20-30 ng/ml) or vitamin D deficiency (serum vitamin D levels <20 ng/ml) were enrolled in the study. Patients were randomly assigned to receive vitamin D supplementation or placebo. Systolic and diastolic blood pressure was measured before the intervention and one and two months thereafter. Of 208 patients enrolled, 171 patients remained for analysis. The effect of vitamin D supplementation on systolic blood pressure was statistically significant in the first and second months after the intervention (P=0.004 and P=0.024, respectively). The effect of vitamin D supplementation on diastolic blood pressure was statistically significant in the first month after the intervention (P=0.046), but not in the second month (P=0.885). No evidence of drug side effects was reported in the two groups. The results of this trial are suggestive of the potential benefits of vitamin D supplementation on blood pressure end points. Therefore, the use of vitamin D may be recommended as an adjuvant drug in the treatment of essential hypertension in patients with vitamin D deficiency because it is safe and well-tolerated by the patients and can significantly reduce the systolic and diastolic blood pressure. Trial registration: Iranian Registry of Clinical Trials registration number: IRCT201703129014N151.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.