Evidence map›Paper›PMID 32951289›Full record

ArticlePhysiological reports2020

Targeted and untargeted metabolomics provide insight into the consequences of glycine-N-methyltransferase deficiency including the novel finding of defective immune function.

Brandon J Eudy, Caitlin E McDermott, Xiuli Liu, Robin P da Silva

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Targeting one-carbon metabolism for cancer immunotherapy.Clinical and translational medicine · 2024
    Review
  3. Review
  4. Review
  5. Metagenomic-Metabolomic Mining ofFrontiers in microbiology · 2022
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Brandon J EudyDepartment of Food Science and Human Nutrition, University of Florida, Gainesville, FL, USA.
Caitlin E McDermottDepartment of Food Science and Human Nutrition, University of Florida, Gainesville, FL, USA.
Xiuli LiuDepartment of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL, USA.
Robin P da SilvaDepartment of Food Science and Human Nutrition, University of Florida, Gainesville, FL, USA.ORCID 0000-0002-6820-5817
University of Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fatty liver disease is increasing along with the prevalence of obesity and type-2 diabetes. Hepatic fibrosis is a major health complication for which there are no efficacious treatment options available. A better understanding of the fundamental mechanisms that contribute to the accumulation of fibrosis is needed. Glycine-N-methyltransferase (GNMT) is a critical enzyme in one-carbon metabolism that serves to regulate methylation and remethylation reactions. GNMT knockout (GNMT

Indexed as

MetabolomeAnimalsDiet, High-FatFibrosisGlycine N-MethyltransferaseLipid MetabolismMaleMatrix Metalloproteinase 12MiceMice, Inbred C57BLNF-kappa BNon-alcoholic Fatty Liver DiseaseVinculinWeight GainGlycine N-MethyltransferaseGnmt protein, mouseMatrix Metalloproteinase 12NF-kappa BVinculinaryl hydrocarbon receptorfibrosisNADone-carbon metabolismtryptophan

Identifiers

PMID32951289
PMCPMC7507444
OpenAlexW3087559008

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.