Evidence map›Paper›PMID 32951272›Full record

ArticleJournal of clinical laboratory analysis2020

Promotive effect of Talin-1 protein on gastric cancer progression through PTK2-PXN-VCL-E-Cadherin-CAPN2-MAPK1 signaling axis.

Hongzhu Yan, Min Guo, Jue Zou, Feng Xiao, Lina Yi, Ying He, Bosheng He

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical laboratory analysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 17 citations in OpenAlex.

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  12. Canadian journal of gastroenterology & hepatology · 2022
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Hongzhu YanDepartment of Pathology, Seventh People's Hospital of Shanghai University of TCM, Shanghai, China.ORCID https://orcid.org/0000-0002-2283-9013
Min GuoDepartment of Pathology, Seventh People's Hospital of Shanghai University of TCM, Shanghai, China.
Jue ZouDepartment of Pathology, Seventh People's Hospital of Shanghai University of TCM, Shanghai, China.
Feng XiaoDepartment of Pathology, Seventh People's Hospital of Shanghai University of TCM, Shanghai, China.
Lina YiDepartment of Pathology, Seventh People's Hospital of Shanghai University of TCM, Shanghai, China.
Ying HeDepartment of Ultrasound, The Tumor Hospital of Nantong University, Nantong, China.
Bosheng HeDepartment of Radiology, The Second Affiliated Hospital of Nantong University, Nantong, China.ORCID https://orcid.org/0000-0001-7968-131X
Shanghai University · CNNantong University · CN

Funding

Shanghai Municipal Commission of Health and Family Planning Project 201840290Shanghai Pudong New District Health Bureau Project PW2019A-18Social Development Fund of Nantong MS22019013
6 · The paper itself

Abstract

objectiveOur research group was aim to explore the molecular mechanism of Talin-1 protein affecting gastric cancer progression through PTK2-PXN-VCL-E-Cadherin-CAPN2-MAPK1 signal axis.

methods12 cases of patients with gastric cancer in this hospital from 2018 to 2019 were collected. Immunohistochemistry assay and Western blotting were used to detect the expression of Talin-1, PXN, E-Cadherin, CAPN2, MAPK1 protein in gastric cancer tissue. Cell migration and invasion were measured by Transwell.

resultsThe results showed that the expression levels of protein Talin-1, PXN and MAPK1 in gastric cancer tissues were significantly higher than that in normal tissue. The number of cell adhesion in the model group was significantly lower than that in the normal group. However, the cell adhesion number in ov-TLN1 was the highest. Transwell results showed that TLN1 could accelerate the migration and invasion abilities of gastric cancer MKN-45 cells. Moreover, Western blotting showed that protein Talin-1, PXN, E-Cadherin, CAPN2, MAPK1 in model group all increased compared with normal group.

conclusionIt indicated that talin-1 protein influenced the development of gastric cancer through PTK2-PXN-VCL-E-Cadherin-CAPN2-MAPK1 signal axis.

Indexed as

Stomach NeoplasmsTalinAntigens, CDCadherinsCalpainCell Line, TumorDisease ProgressionFocal Adhesion Kinase 1HumansImmunohistochemistryMAP Kinase Signaling SystemPaxillinStomachVinculinAntigens, CDCadherinsCalpainCAPN2 protein, humanCDH1 protein, humanFocal Adhesion Kinase 1PaxillinPTK2 protein, humanPXN protein, humanTalinTLN1 protein, humanVCL protein, humanVinculingastric cancermechanismMKN-45 cellssignaling axistalin-1

Identifiers

PMID32951272
PMCPMC7755796
OpenAlexW3087154057

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.