Evidence map›Paper›PMID 32951262›Full record

Trial reportAnnals of neurology2020

Subthalamic Nucleus Deep Brain Stimulation Modulates 2 Distinct Neurocircuits.

Lunhao Shen, Changqing Jiang, Catherine S Hubbard, Jianxun Ren, Changgeng He, Danhong Wang, Louisa Dahmani, Yi Guo, Yiming Liu, Shujun Xu and 4 more

Abstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Annals of neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Lunhao Shen *National Engineering Laboratory for Neuromodulation, School of Aerospace Engineering, Tsinghua University, Beijing, China.
Changqing Jiang *National Engineering Laboratory for Neuromodulation, School of Aerospace Engineering, Tsinghua University, Beijing, China.
Catherine S HubbardDepartment of Neuroscience, Medical University of South Carolina, Charleston, SC, USA.
Jianxun RenNational Engineering Laboratory for Neuromodulation, School of Aerospace Engineering, Tsinghua University, Beijing, China.
Changgeng HeNational Engineering Laboratory for Neuromodulation, School of Aerospace Engineering, Tsinghua University, Beijing, China.
Danhong WangAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Louisa DahmaniAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Yi GuoPeking Union Medical College Hospital, Beijing, China.
Yiming LiuQilu Hospital of Shandong University, Jinan, China.
Shujun XuQilu Hospital of Shandong University, Jinan, China.
Fangang MengBeijing Tiantan Hospital, Capital Medical University, Beijing, China.
Jianguo ZhangBeijing Tiantan Hospital, Capital Medical University, Beijing, China.
Hesheng LiuAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.ORCID 0000-0002-7233-1509
Luming LiNational Engineering Laboratory for Neuromodulation, School of Aerospace Engineering, Tsinghua University, Beijing, China.

Funding

The neural network of OCD, linking NHP and human studiesP50MH106435 · NIMH · UNIVERSITY OF ROCHESTER · PI STEVEN A RASMUSSEN · 2015 to 2026
$28.9M
COCA: Project 4. Neurocircuit Strategy to Decrease Cocaine Cue ReactivityP50DA046373 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI HANLON, COLLEEN A · 2019 to 2023
$9.9M
Mapping the intrinsic functional organization of auditory cortex in individual subjects using 7T MRIR01DC017991 · NIDCD · MASSACHUSETTS GENERAL HOSPITAL · PI AHVENINEN, JYRKI · 2019 to 2023
$4.0M
Translating The Individualized Functional Connectome To Surgical PlanningR01NS091604 · NINDS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI LIU, HESHENG · 2015 to 2019
$2.1M
Understanding Functional Connectivity Abnormalities In Individual Patients with PsychosisK01MH111802 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI WANG, DANHONG · 2017 to 2021
$931k
Cerebro-cerebellar circuitry in the pathophysiology of auditory hallucinations: dysmetria of auditory perceptual processing?R21MH121831 · NIMH · MCLEAN HOSPITAL · PI LIU, HESHENG, SHINN, ANN KYUNGAH · 2019 to 2020
$451k
NIDA NIH HHS P50 DA046373NIDCD NIH HHS R01 DC017991NIDCD NIH HHS R01DC017991NIMH NIH HHS K01 MH111802NIMH NIH HHS P50 MH106435NIMH NIH HHS P50MH106435NIMH NIH HHS R21 MH121831NIMH NIH HHS R21MH121831NINDS NIH HHS 1R01NS091604NINDS NIH HHS R01 NS091604
6 · The paper itself

Abstract

objectiveCurrent understanding of the neuromodulatory effects of deep brain stimulation (DBS) on large-scale brain networks remains elusive, largely due to the lack of techniques that can reveal DBS-induced activity at the whole-brain level. Using a novel 3T magnetic resonance imaging (MRI)-compatible stimulator, we investigated whole-brain effects of subthalamic nucleus (STN) stimulation in patients with Parkinson disease.

methodsFourteen patients received STN-DBS treatment and participated in a block-design functional MRI (fMRI) experiment, wherein stimulations were delivered during "ON" blocks interleaved with "OFF" blocks. fMRI responses to low-frequency (60Hz) and high-frequency(130Hz) STN-DBS were measured 1, 3, 6, and 12 months postsurgery. To ensure reliability, multiple runs (48 minutes) of fMRI data were acquired at each postsurgical visit. Presurgical resting-state fMRI (30 minutes) data were also acquired.

resultsTwo neurocircuits showed highly replicable, but distinct responses to STN-DBS. A circuit involving the globus pallidus internus (GPi), thalamus, and deep cerebellar nuclei was significantly activated, whereas another circuit involving the primary motor cortex (M1), putamen, and cerebellum showed DBS-induced deactivation. These 2 circuits were dissociable in terms of their DBS-induced responses and resting-state functional connectivity. The GPi circuit was frequency-dependent, selectively responding to high-frequency stimulation, whereas the M1 circuit was responsive in a time-dependent manner, showing enhanced deactivation over time. Finally, activation of the GPi circuit was associated with overall motor improvement, whereas M1 circuit deactivation was related to reduced bradykinesia.

interpretationConcurrent DBS-fMRI using 3T revealed 2 distinct circuits that responded differentially to STN-DBS and were related to divergent symptoms, a finding that may provide novel insights into the neural mechanisms underlying DBS. ANN NEUROL 2020;88:1178-1193.

Indexed as

Cerebellar NucleiCerebellumDeep Brain StimulationFemaleGlobus PallidusHumansMagnetic Resonance ImagingMaleMiddle AgedMotor CortexNeural PathwaysParkinson DiseasePutamenSubthalamic NucleusThalamus

Identifiers

PMID32951262
PMCPMC8087166

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.