ArticleJournal of child psychology and psychiatry, and allied disciplines2021
The longitudinal association between externalizing behavior and frontoamygdalar resting-state functional connectivity in late adolescence and young adulthood.
Article in Journal of child psychology and psychiatry, and allied disciplines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Preliminary examination of the effects of an early parenting intervention on amygdala-orbitofrontal cortex resting-state functional connectivity among high-risk children: A randomized clinical trial.Development and psychopathology · 2025Trial
- The sex-specific role of adrenal androgens in youth psychopathology.Translational psychiatry · 2026Article
- Global topology of brain-wide co-fluctuations links task states, personality, and behavioral symptom dimensions.bioRxiv : the preprint server for biology · 2026Article
- A general framework for investigating neurodevelopment of brain functional networks using multisite and longitudinal neuroimaging.The annals of applied statistics · 2026Article
- Associations between amygdala connectivity and experienced discrimination in children.bioRxiv : the preprint server for biology · 2026Article
- Synchrony between brain age and internalising and externalising symptoms across adolescence.medRxiv : the preprint server for health sciences · 2026Article
- Frontostriatal Networks Undergo Functional Specialization during Adolescence That Follows a Ventral-Dorsal Gradient: Developmental Trajectories and Longitudinal Associations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Longitudinally Predicting Behavioral Challenges From Executive Functioning in Youth With Down Syndrome.American journal on intellectual and developmental disabilities · 2025Article
- Sexual Minority Identity and Risky Alcohol Use: the Moderating Role of Aggressive Behavior.Journal of youth and adolescence · 2025Article
- Coupled changes between ruminating thoughts and resting-state brain networks during the transition into adulthood.Molecular psychiatry · 2024Article
- Comparison of emotional and behavioral regulation between metopic and sagittal synostosis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Article
- Corticolimbic connectivity mediates the relationship between pubertal timing and mental health problems.Psychological medicine · 2023Article
- Sex differences in externalizing and internalizing traits and ventral striatal responses to monetary loss.Journal of psychiatric research · 2023Article
- Childhood trauma, earlier pubertal timing, and psychopathology in adolescence: The role of corticolimbic development.Developmental cognitive neuroscience · 2023Article
- Psychopathic traits and altered resting-state functional connectivity in incarcerated adolescent girls.Frontiers in neuroimaging · 2023Article
- Intrinsic connectivity within the affective salience network moderates adolescent susceptibility to negative and positive peer norms.Scientific reports · 2022Article
- Increased amygdala and decreased frontolimbic r esting- s tate functional connectivity in children with aggressive behavior.Social cognitive and affective neuroscience · 2022Article
- Frontoamygdala hyperconnectivity predicts affective dysregulation in adolescent moderate-severe TBI.Frontiers in rehabilitation sciences · 2022Article
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4 authors.
Funding
Abstract
backgroundExternalizing behavior has been attributed, in part, to decreased frontolimbic control over amygdala activation. However, little is known about developmental trajectories of frontoamygdalar functional connectivity and its relation to externalizing behavior. The present study addresses this gap by examining longitudinal associations between adolescent and adult externalizing behavior and amygdala-anterior cingulate cortex (ACC) and amygdala-orbitofrontal cortex (OFC) resting-state functional connectivity in a sample of 111 typically developing participants aged 11-23 at baseline.
methodsParticipants completed two-to-four data waves spaced approximately two years apart, resulting in a total of 309 data points. At each data wave, externalizing behavior was measured using the Externalizing Behavior Broadband Scale from the Achenbach Youth/Adult Self-Report questionnaire. Resting-state fMRI preprocessing was performed using FSL. Amygdala functional connectivity was examined using AFNI. The longitudinal association between externalizing behavior and amygdala-ACC/OFC functional connectivity was examined using linear mixed effect models in R.
resultsExternalizing behavior was associated with increased amygdala-ACC and amygdala-OFC resting-state functional connectivity across adolescence and young adulthood. For amygdala-ACC connectivity, externalizing behavior at baseline primarily drove this association, whereas for amygdala-OFC functional connectivity, change in externalizing behavior relative to baseline drove the main effect of externalizing behavior on amygdala-OFC functional connectivity. No evidence was found for differential developmental trajectories of frontoamygdalar connectivity for different levels of externalizing behavior (i.e., age-by-externalizing behavior interaction effect).
conclusionsHigher externalizing behavior is associated with increased resting-state attunement between the amygdala and ACC/OFC, perhaps indicating a generally more vigilant state for neural networks important for emotional processing and control.
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