Evidence map›Paper›PMID 32951070›Full record

ArticleSleep & breathing = Schlaf & Atmung2021

Sleep variability, 6-sulfatoxymelatonin, and diabetic retinopathy.

Supamas Sirisreetreerux, Tharikarn Sujirakul, Hataikarn Nimitphong, Sittichai Pinyopodjanard, Sunee Saetung, La-Or Chailurkit, Naricha Chirakalwasan, Ben S Gerber, Sirimon Reutrakul

Abstract read
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In one paragraph

Article in Sleep & breathing = Schlaf & Atmung, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. Effects of Melatonin on Diabetic Neuropathy and Retinopathy.International journal of molecular sciences · 2021
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Supamas SirisreetreeruxDivision of Endocrinology and Metabolism, Mahidol University, Bangkok, Thailand.
Tharikarn SujirakulDepartment of Ophthalmology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Hataikarn NimitphongDivision of Endocrinology and Metabolism, Mahidol University, Bangkok, Thailand.
Sittichai PinyopodjanardDivision of Endocrinology and Metabolism, Mahidol University, Bangkok, Thailand.
Sunee SaetungDivision of Endocrinology and Metabolism, Mahidol University, Bangkok, Thailand.
La-Or ChailurkitDivision of Endocrinology and Metabolism, Mahidol University, Bangkok, Thailand.
Naricha ChirakalwasanExcellence Center for Sleep Disorders, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand.
Ben S GerberDivision of Academic Internal Medicine and Geriatrics, University of Illinois at Chicago, Chicago, IL, USA.
Sirimon ReutrakulDivision of Endocrinology and Metabolism, Mahidol University, Bangkok, Thailand. sreutrak@uic.edu.ORCID http://orcid.org/0000-0002-0686-1069
Mahidol University · THThai Red Cross Society · THUniversity of Illinois Chicago · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeRecent evidence suggests that diabetic retinopathy (DR) is associated with abnormal melatonin regulation, possibly related to dysfunction of the melanopsin-expressing intrinsically photosensitive retinal ganglion cells. This study explored melatonin regulation in type 2 diabetes (T2D) patients with DR and its relation to sleep and circadian functioning.

methodsThirty-five participants (10 non-diabetic controls, 10 T2D without DR, and 15 T2D with DR) were recruited. Overnight urine 6-sulfatoxymelatonin (aMT6s) and objective sleep and wrist activity (7-day actigraphy) were obtained.

resultsAfter adjusting for covariates, having T2D with DR was significantly associated with lower urinary aMT6s (β = - 1.369, p = 0.004) compared with controls, while having T2D without DR was not (p = 0.418). T2D patients with DR reported poorer sleep quality (p = 0.014) and had greater variability of sleep duration (p = 0.017) than others, while no differences were found in sleep duration, efficiency, and rest-activity rhythm. After adjusting for covariates, lower nocturnal aMT6s was significantly associated with greater sleep variability.

conclusionT2D patients with DR exhibited low overnight production of aMT6s which likely contributed to sleep irregularities possibly due to weak circadian signaling. Whether or not melatonin supplementation could improve health in T2D patients with DR remains to be explored.

Indexed as

AdultCase-Control StudiesDiabetes Mellitus, Type 2Diabetic RetinopathyFemaleHumansMaleMelatoninMiddle AgedSleep6-sulfatoxymelatoninMelatonin6-SulfatoxymelatoninDiabetesRetinopathySleep variability

Identifiers

PMID32951070
OpenAlexW3087245454

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.