ArticlePathobiology : journal of immunopathology, molecular and cellular biology2021
Placental Pathology Findings during and after SARS-CoV-2 Infection: Features of Villitis and Malperfusion.
Article in Pathobiology : journal of immunopathology, molecular and cellular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 4 of them syntheses that pooled it.
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Who cites it
77 citing papers in PubMed, 4 syntheses or guidelines pooled it, 132 citations in OpenAlex.
- Evaluation of the effect of SARS-CoV-2 infection on Doppler ultrasound and placental findings of pregnant women: a systematic review and meta-analysis.Ultrasonography (Seoul, Korea) · 2024Pooled it
- Pooled it
- Fetoplacental transmission and placental response to SARS-CoV-2: Evidence from the literature.Frontiers in medicine · 2022Pooled it
- Placental histopathology after SARS-CoV-2 infection in pregnancy: a systematic review and meta-analysis.American journal of obstetrics & gynecology MFM · 2021Pooled it
- Placentas From COVID-19-Positive Mothers: A Morphological Study of 20 Cases in Marrakesh, Morocco.Cureus · 2026Article
- Changes in Placentas of Pregnant Women Infected with COVID-19.International journal of molecular sciences · 2025Article
- Placental histological differences between COVID19 infected and non-infected mothers during third trimester of pregnancy: a retrospective cohort study.BMC pregnancy and childbirth · 2025Article
- The effect of COVID-19 on placental functioning in South African pregnancies: investigation of kisspeptin expression and vascular and inflammatory alterations.Histochemistry and cell biology · 2025Article
- Gestational weight gain during pregnancy is the risk factor for Omicron infection: a retrospective case-control study.BMC pregnancy and childbirth · 2024Article
- Enhancing the Diagnostic Accuracy of Placental Pathology by Using the Amsterdam Consensus Criteria.Cureus · 2024Article
- Preeclampsia in the Context of COVID-19: Mechanisms, Pathophysiology, and Clinical Outcomes.American journal of reproductive immunology (New York, N.Y. : 1989) · 2024Review
- The effect of long-term COVID-19 infection on maternal and fetal complications: a retrospective cohort study conducted at a single center in China.Scientific reports · 2024Article
- Prompt Placental Histopathological and Immunohistochemical Assessment after SARS-CoV-2 Infection during Pregnancy-Our Perspective of a Small Group.International journal of molecular sciences · 2024Article
- Maternal SARS-CoV-2 infection in pregnancy disrupts gene expression in Hofbauer cells with limited impact on cytotrophoblasts.PLoS pathogens · 2024Article
- Maternal COVID-19 exposure and placental characteristics.PloS one · 2024Article
- Maternal, Perinatal, and Neonatal Outcomes of COVID-19 Severity in Pregnant Women: A Retrospective Study from Oman.Oman medical journal · 2023Article
- Activation of the Interferon Pathway in Trophoblast Cells Productively Infected with SARS-CoV-2.Stem cells and development · 2023Article
- Diminished antiviral innate immune gene expression in the placenta following a maternal SARS-CoV-2 infection.American journal of obstetrics and gynecology · 2023Article
- Impact of Co-Occurrence of Obesity and SARS-CoV-2 Infection during Pregnancy on Placental Pathologies and Adverse Birth Outcomes: A Systematic Review and Narrative Synthesis.Pathogens (Basel, Switzerland) · 2023Review
- Severity of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Pregnancy in Ontario: A Matched Cohort Analysis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
17 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since the outbreak of coronavirus disease 2019 (COVID-19), there has been a debate whether pregnant women are at a specific risk for COVID-19 and whether it might be vertically transmittable through the placenta. We present a series of five placentas of SARS coronavirus 2 (SARS-CoV-2)-positive women who had been diagnosed with mild symptoms of COVID-19 or had been asymptomatic before birth. We provide a detailed histopathologic description of morphological changes accompanied by an analysis of presence of SARS-CoV-2 in the placental tissue. All placentas were term deliveries (40th and 41st gestational weeks). One SARS-CoV-2-positive patient presented with cough and dyspnoea. This placenta showed prominent lymphohistiocytic villitis and intervillositis and signs of maternal and foetal malperfusion. Viral RNA was present in both placenta tissue and the umbilical cord and could be visualized by in situ hybridization in the decidua. SARS-CoV-2 tests were negative at the time of delivery of 3/5 women, and their placentas did not show increased inflammatory infiltrates. Signs of maternal and/or foetal malperfusion were present in 100% and 40% of cases, respectively. There was no transplacental transmission to the infants. In our cohort, we can document different time points regarding SARS-CoV-2 infection. In acute COVID-19, prominent lymphohistiocytic villitis may occur and might potentially be attributable to SARS-CoV-2 infection of the placenta. Furthermore, there are histopathological signs of maternal and foetal malperfusion, which might have a relationship to an altered coagulative or microangiopathic state induced by SARS-CoV-2, yet this cannot be proven considering a plethora of confounding factors.
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