ReviewCurrent opinion in cell biology2020
A single-cell view of spermatogonial stem cells.
Review in Current opinion in cell biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 60 citations in OpenAlex.
- Single-Cell RNA Sequencing Reveals Dynamic Transcriptional Landscape of Testicular Maturation in Dezhou Donkeys.Animals : an open access journal from MDPI · 2026Article
- Decoding the heterogeneity of human undifferentiated spermatogonia reveals RAS-dependent regulation of stem cell fate.Cell reports · 2026Article
- A Comprehensive Mass Spectrometry-Based Proteomic Dataset of Human Spermatozoa.Scientific data · 2025Article
- Rewinding the clock: mechanisms of dedifferentiation.Current opinion in genetics & development · 2025Review
- Dynamic transcriptomic and regulatory networks underpinning the transition from fetal primordial germ cells to spermatogonia in mice.Cell proliferation · 2025Article
- Single-cell RNA sequencing reveals transcriptomic landscape and potential targets for human testicular ageing.Human reproduction (Oxford, England) · 2024Article
- Single-Cell RNA Sequencing Reveals an Atlas of Hezuo Pig Testis Cells.International journal of molecular sciences · 2024Article
- Single-cell RNA sequencing technology in human spermatogenesis: Progresses and perspectives.Molecular and cellular biochemistry · 2024Review
- Single-Nucleus RNA-Seq Reveals Spermatogonial Stem Cell Developmental Pattern in Shaziling Pigs.Biomolecules · 2024Article
- Splicing factor SRSF1 is essential for homing of precursor spermatogonial stem cells in mice.eLife · 2024Article
- Review
- Ubiquitin C-terminal hydrolase L1 (UCHL1), a double-edged sword in mammalian oocyte maturation and spermatogenesis.Cell proliferation · 2023Review
- Transcriptome Profiling of Developing Testes and First Wave of Spermatogenesis in the Rat.Genes · 2023Article
- Human spermatogonial stem cells and their niche in male (in)fertility: novel concepts from single-cell RNA-sequencing.Human reproduction (Oxford, England) · 2023Review
- Fungal biotechnology: From yesterday to tomorrow.Frontiers in fungal biology · 2023Review
- Application of single-cell RNA sequencing on human testicular samples: a comprehensive review.International journal of biological sciences · 2023Review
- Overexpression ofBiology · 2022Article
- Testis-enrichedTranslational andrology and urology · 2022Article
- Recent Update on Retinoic Acid-Driven Initiation of Spermatogonial Differentiation.Frontiers in cell and developmental biology · 2022Article
- Single-cell transcriptomics reveals male germ cells and Sertoli cells developmental patterns in dairy goats.Frontiers in cell and developmental biology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Spermatogonial stem cells (SSCs) are essential for long-term spermatogenesis and are the subject of considerable clinical interest, as 'SSC therapy' has the potential to cure some forms of male infertility. Recently, we have learned more about SSCs and spermatogenesis in general from a plethora of studies that performed single-cell RNA sequencing (scRNAseq) analysis on dissociated cells from human, macaque, and/or mice testes. Here, we discuss what scRNAseq analysis has revealed about SSC precursor cells, the initial generation of SSCs during perinatal development, and their heterogeneity once established. scRNAseq studies have also uncovered unexpected heterogeneity of the larger class of cells that includes SSCs - undifferentiated spermatogonia. This raises the controversial possibility that multiple SSC subsets exist, which has implications for mechanisms underlying spermatogenesis and future SSC therapeutic approaches.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.