Evidence map›Paper›PMID 32950876›Full record

ArticleCell calcium2020

Vascular Kv7 channels control intracellular Ca

Yuan-Ming Tsai, Frederick Jones, Pierce Mullen, Karen E Porter, Derek Steele, Chris Peers, Nikita Gamper

Open access · hybridAbstract read
In one paragraph

Article in Cell calcium, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. HBasic research in cardiology · 2025
    Article
  4. KAmerican journal of physiology. Renal physiology · 2022
    Article
  5. Article
  6. Vasopressin-stimulated ORAI1 expression and store-operated CaJournal of molecular medicine (Berlin, Germany) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Yuan-Ming TsaiSchool of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, United Kingdom; Division of Thoracic Surgery, Department of Surgery, Tri-Service General Hospital, National Defence Medical Centre, Taipei 11490, Taiwan. Electronic address: umymt@leeds.ac.uk.
Frederick JonesSchool of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, United Kingdom.
Pierce MullenSchool of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, United Kingdom.
Karen E PorterLeeds Institute of Cardiovascular and Metabolic Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, LS2 9JT, United Kingdom.
Derek SteeleSchool of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, United Kingdom.
Chris PeersLeeds Institute of Cardiovascular and Metabolic Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, LS2 9JT, United Kingdom.
Nikita GamperSchool of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, United Kingdom. Electronic address: n.gamper@leeds.ac.uk.
University of Leeds · GBTri-Service General Hospital · TW

Funding

Biotechnology and Biological Sciences Research Council BB/R003068/1Biotechnology and Biological Sciences Research Council BB/R02104X/1British Heart Foundation RG/16/6/32233
6 · The paper itself

Abstract

Voltage-gated Kv7 (or KCNQ) channels control activity of excitable cells, including vascular smooth muscle cells (VSMCs), by setting their resting membrane potential and controlling other excitability parameters. Excitation-contraction coupling in muscle cells is mediated by Ca

Indexed as

AnimalsCalciumCalcium Channel BlockersCalcium ChannelsCalcium SignalingCells, CulturedEndoplasmic ReticulumGene Expression RegulationHEK293 CellsHumansIntracellular SpaceKCNQ Potassium ChannelsMammary ArteriesMuscle, Smooth, VascularRatsType C PhospholipasesCalciumCalcium Channel BlockersCalcium ChannelsKCNQ Potassium ChannelsType C PhospholipasesVasopressinsCalciumKv7Phospholipase CRetigabineT-type Ca(2+)channelsVascular smooth muscle cellVasopressin

Identifiers

PMID32950876
PMCPMC7695684
OpenAlexW3082790064

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.