Evidence map›Paper›PMID 32950782›Full record

ArticleNeurobiology of aging2020

Linking anatomical and physiological markers of auditory system degeneration with behavioral hearing assessments in a mouse (Mus musculus) model of age-related hearing loss.

Anastasiya Kobrina, Katrina M Schrode, Laurel A Screven, Hamad Javaid, Madison M Weinberg, Garrett Brown, Ryleigh Board, Dillan F Villavisanis, Micheal L Dent, Amanda M Lauer

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.1field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 48 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Anastasiya KobrinaDepartment of Psychology, University at Buffalo SUNY, Buffalo, NY, USA.
Katrina M SchrodeDepartment of Otolaryngology-Head and Neck Surgery and Center for Hearing and Balance, Johns Hopkins University, Baltimore, MD, USA.
Laurel A ScrevenDepartment of Otolaryngology-Head and Neck Surgery and Center for Hearing and Balance, Johns Hopkins University, Baltimore, MD, USA.
Hamad JavaidDepartment of Otolaryngology-Head and Neck Surgery and Center for Hearing and Balance, Johns Hopkins University, Baltimore, MD, USA.
Madison M WeinbergDepartment of Otolaryngology-Head and Neck Surgery and Center for Hearing and Balance, Johns Hopkins University, Baltimore, MD, USA.
Garrett BrownDepartment of Otolaryngology-Head and Neck Surgery and Center for Hearing and Balance, Johns Hopkins University, Baltimore, MD, USA.
Ryleigh BoardDepartment of Otolaryngology-Head and Neck Surgery and Center for Hearing and Balance, Johns Hopkins University, Baltimore, MD, USA.
Dillan F VillavisanisDepartment of Otolaryngology-Head and Neck Surgery and Center for Hearing and Balance, Johns Hopkins University, Baltimore, MD, USA.
Micheal L DentDepartment of Psychology, University at Buffalo SUNY, Buffalo, NY, USA.
Amanda M LauerDepartment of Otolaryngology-Head and Neck Surgery and Center for Hearing and Balance, Johns Hopkins University, Baltimore, MD, USA. Electronic address: alauer2@jhmi.edu.
Johns Hopkins University · USUniversity at Buffalo, State University of New York · US

Funding

Training Program in Hearing and BalanceT32DC000023 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI CULLEN, KATHLEEN E · 1989 to 2025
$8.7M
Role of olivocochlear efferents in age-related hearing dysfunctionR01DC017620 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI LAUER, AMANDA M. · 2018 to 2022
$2.2M
Supplement for temporal bone tissue scanning equipmentR01DC016641 · NIDCD · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI DENT, MICHEAL L, LAUER, AMANDA M. · 2018 to 2022
$2.2M
Complex Sound Perception in MiceR01DC012302 · NIDCD · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI DENT, MICHEAL L · 2013 to 2017
$1.9M
The Effects of Aging on Hearing in the CBA/CaJ Mice Across the LifespanF31DC016545 · NIDCD · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI KOBRINA, ANASTASIYA · 2017 to 2018
$58k
NIDCD NIH HHS F31 DC016545NIDCD NIH HHS R01 DC012302NIDCD NIH HHS R01 DC016641NIDCD NIH HHS R01 DC017620NIDCD NIH HHS T32 DC000023
6 · The paper itself

Abstract

Age-related hearing loss is a very common sensory disability, affecting one in three older adults. Establishing a link between anatomical, physiological, and behavioral markers of presbycusis in a mouse model can improve the understanding of this disorder in humans. We measured age-related hearing loss for a variety of acoustic signals in quiet and noisy environments using an operant conditioning procedure and investigated the status of peripheral structures in CBA/CaJ mice. Mice showed the greatest degree of hearing loss in the last third of their lifespan, with higher thresholds in noisy than in quiet conditions. Changes in auditory brainstem response thresholds and waveform morphology preceded behavioral hearing loss onset. Loss of hair cells, auditory nerve fibers, and signs of stria vascularis degeneration were observed in old mice. The present work underscores the difficulty in ascribing the primary cause of age-related hearing loss to any particular type of cellular degeneration. Revealing these complex structure-function relationships is critical for establishing successful intervention strategies to restore hearing or prevent presbycusis.

Indexed as

AgingAnimalsCochleaDisease Models, AnimalEvoked Potentials, Auditory, Brain StemHair Cells, AuditoryHearing LossMice, Inbred CBANerve DegenerationPsychoacousticsAnimal psychoacousticsARHLAuditory brainstem responseCochlear degenerationCochlear nucleusOlivocochlear

Identifiers

PMID32950782
PMCPMC8080312
OpenAlexW3080441447

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.