Evidence map›Paper›PMID 32950745›Full record

ReviewCurrent opinion in insect science2021

Control of the insect metamorphic transition by ecdysteroid production and secretion.

Xueyang Pan, Robert P Connacher, Michael B O'Connor

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in insect science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 104 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Evolutionary dynamics of the arthropod molting machinery.Molecular biology and evolution · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Insect Sterols and Steroids.Advances in experimental medicine and biology · 2026
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Symbiotic bracovirus of a parasite modulate host ecdysis process.Cellular and molecular life sciences : CMLS · 2025
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Xueyang PanDepartment of Genetics, Cell Biology and Development, University of Minnesota, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, USA.
Robert P ConnacherDepartment Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, USA.
Michael B O'ConnorDepartment of Genetics, Cell Biology and Development, University of Minnesota, USA. Electronic address: moconnor@umn.edu.
University of Minnesota · US

Funding

Inter-organ signals regulating metabolism, physiology and developmental timingR35GM118029 · NIGMS · UNIVERSITY OF MINNESOTA · PI O'CONNOR, MICHAEL BRENDAN · 2016 to 2025
$3.8M
Request to Transfer R01GM105707-03 Novel regulatory mechanisms of Drosophila Pumilio and NanosR01GM105707 · NIGMS · UNIVERSITY OF MINNESOTA · PI GOLDSTROHM, AARON CHARLES · 2013 to 2022
$2.7M
NIGMS NIH HHS R01 GM105707NIGMS NIH HHS R35 GM118029
6 · The paper itself

Abstract

Ecdysteroids are a class of steroid hormones that controls molting and metamorphic transitions in Ecdysozoan species including insects, in which ecdysteroid biosynthesis and its regulation have been extensively studied. Insect ecdysteroids are produced from dietary sterols by a series of reduction-oxidation reactions in the prothoracic gland and in Drosophila they are released into the hemolymph via vesicle-mediated secretion at the time of metamorphosis. To initiate precisely controlled ecdysteroid pulses, the prothoracic gland functions as a central node integrating both intrinsic and extrinsic signals to control ecdysteroid biosynthesis and secretion. In this review, we outline recent progress in the characterization of ecdysone biosynthesis and steroid trafficking pathways and the discoveries of novel factors regulating prothoracic gland function.

Indexed as

AnimalsBodily SecretionsEcdysteroidsInsectaMetamorphosis, BiologicalEcdysteroids

Identifiers

PMID32950745
PMCPMC7965781
OpenAlexW3087027680

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.