Evidence map›Paper›PMID 32950736›Full record

ArticleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2020

The optimal duration of antimicrobial therapy for lower respiratory tract infection in patients with neuromuscular disorders based on a clone library analysis of the bacterial 16S rRNA gene sequence.

Masaru Kawamura, Takayuki Hoshina, Masato Ogawa, Noboru Yamamoto, Kaoru Haro, Tokiko Kumadaki, Kazumasa Fukuda, Koichi Kusuhara

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Masaru KawamuraDepartment of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Takayuki HoshinaDepartment of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Japan. Electronic address: hoshina@med.uoeh-u.ac.jp.
Masato OgawaDepartment of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Noboru YamamotoDepartment of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Kaoru HaroDepartment of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan; Department of Microbiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Tokiko KumadakiDepartment of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Kazumasa FukudaDepartment of Microbiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Koichi KusuharaDepartment of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
University of Occupational and Environmental Health Japan · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe aim of this study is to determine the optimal duration of antimicrobial therapy for lower respiratory tract infection (LRTI) in neuromuscular disorder (NMD) patients.

methodsThis prospective study included 13 episodes from 9 NMD patients hospitalized for bacterial LRTI. Sputum samples were collected from these patients during the three consecutive days after their admission. Bacterial cell counts and the proportion of the most predominant bacterium identified by a clone library analysis of the bacterial 16S rRNA gene sequence in the samples obtained before antimicrobial therapy were serially investigated.

resultsAll episodes were initially treated with ampicillin/sulbactam. In 12 episodes with a therapeutic effect, the bacterial cell counts in the samples obtained on the third day of therapy were significantly lower than those before therapy (P = 0.0013). In most of these episodes, the most predominant bacterium in the sample obtained before therapy was undetectable by the third day of therapy. In the one patient without a therapeutic effect, neither the bacterial cell counts nor the proportion of the most predominant bacterium in the sample obtained before therapy decrease after therapy.

conclusionShort-term antimicrobial therapy is sufficiently effective for LRTI in NMD patients if the initial therapy is effective.

Indexed as

AdolescentAdultAmpicillinAnti-Bacterial AgentsBacteriaBacterial InfectionsChildChild, PreschoolDNA, BacterialDuration of TherapyFemaleHumansMaleNeuromuscular DiseasesProspective StudiesRespiratory Tract InfectionsAmpicillinAnti-Bacterial AgentsDNA, BacterialRNA, Ribosomal, 16SSulbactamAntimicrobial therapyBacterial lower respiratory tract infectionClone library analysisMicrobiomeNeuromuscular disorders

Identifiers

PMID32950736
PMCPMC7497799
OpenAlexW3085019727

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.