Evidence map›Paper›PMID 32950601›Full record

ArticleMatrix biology : journal of the International Society for Matrix Biology2020

Collagen XI regulates the acquisition of collagen fibril structure, organization and functional properties in tendon.

Mei Sun, Eric Y Luo, Sheila M Adams, Thomas Adams, Yaping Ye, Snehal S Shetye, Louis J Soslowsky, David E Birk

Open access · hybridAbstract read
In one paragraph

Article in Matrix biology : journal of the International Society for Matrix Biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 79 citations in OpenAlex.

  1. Article
  2. Article
  3. Ocular and Systemic Findings in COL2A1 and COL11A1 Stickler Syndrome.American journal of medical genetics. Part A · 2026
    Article
  4. Animals : an open access journal from MDPI · 2026
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2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Mei SunDepartment of Molecular Pharmacology & Physiology, University of South Florida, Morsani College of Medicine, 12901 Bruce B. Downs Blvd, Tampa, FL, 33612 USA.
Eric Y LuoDepartment of Molecular Pharmacology & Physiology, University of South Florida, Morsani College of Medicine, 12901 Bruce B. Downs Blvd, Tampa, FL, 33612 USA.
Sheila M AdamsDepartment of Molecular Pharmacology & Physiology, University of South Florida, Morsani College of Medicine, 12901 Bruce B. Downs Blvd, Tampa, FL, 33612 USA.
Thomas AdamsDepartment of Molecular Pharmacology & Physiology, University of South Florida, Morsani College of Medicine, 12901 Bruce B. Downs Blvd, Tampa, FL, 33612 USA.
Yaping YeMcKay Orthopedic Research Laboratory, University of Pennsylvania, Stemmler Hall, 3450 Hamilton Walk, Philadelphia, PA, 19104 USA.
Snehal S ShetyeMcKay Orthopedic Research Laboratory, University of Pennsylvania, Stemmler Hall, 3450 Hamilton Walk, Philadelphia, PA, 19104 USA.
Louis J SoslowskyMcKay Orthopedic Research Laboratory, University of Pennsylvania, Stemmler Hall, 3450 Hamilton Walk, Philadelphia, PA, 19104 USA.
David E BirkDepartment of Molecular Pharmacology & Physiology, University of South Florida, Morsani College of Medicine, 12901 Bruce B. Downs Blvd, Tampa, FL, 33612 USA; McKay Orthopedic Research Laboratory, University of Pennsylvania, Stemmler Hall, 3450 Hamilton Walk, Philadelphia, PA, 19104 USA. Electronic address: dbirk@usf.edu.
University of South Florida · USUniversity of Pennsylvania · US

Funding

The Role of Hyaluronic Acid Receptors in Tendon HealingP30AR050950 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI PIGNOLO, ROBERT JOHN · 2006 to 2015
$6.2M
Regulated Assembly of the Tendon Extracellular MatrixR01AR044745 · NIAMS · UNIVERSITY OF SOUTH FLORIDA · PI BIRK, DAVID E · 1997 to 2016
$5.0M
Collagen XI and XI/V regulatory mechanisms in assembly of tendon hierarchical structure and acquisition of mechanical properties in development and injury responseR01AR073231 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI SOSLOWSKY, LOUIS J · 2018 to 2022
$2.0M
NIAMS NIH HHS P30 AR050950NIAMS NIH HHS R01 AR044745NIAMS NIH HHS R01 AR073231
6 · The paper itself

Abstract

Collagen XI is a fibril-forming collagen that regulates collagen fibrillogenesis. Collagen XI is normally associated with collagen II-containing tissues such as cartilage, but it also is expressed broadly during development in collagen I-containing tissues, including tendons. The goals of this study are to define the roles of collagen XI in regulation of tendon fibrillar structure and the relationship to function. A conditional Col11a1-null mouse model was created to permit the spatial and temporal manipulation of Col11a1 expression. We hypothesize that collagen XI functions to regulate fibril assembly, organization and, therefore, tendon function. Previous work using cho mice with ablated Col11a1 alleles supported roles for collagen XI in tendon fibril assembly. Homozygous cho/cho mice have a perinatal lethal phenotype that limited the studies. To circumvent this, a conditional Col11a1

Indexed as

AnimalsCartilageCollagen Type XIDisease Models, AnimalExtracellular MatrixFibrillar CollagensGene Expression Regulation, DevelopmentalHumansMiceMice, Inbred C57BLMice, KnockoutMicroscopy, Electron, TransmissionSkinTendonsCollagen Type XIFibrillar CollagensCol11a1Collagen fibrillogenesisCollagen XIConditional mouse modelTendonTendon biomechanicsTendon structure

Identifiers

PMID32950601
PMCPMC7722227
OpenAlexW3087408011

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.