ArticleArchives of physical medicine and rehabilitation2021
Reliability and Validity of Pupillary Response During Dual-Task Balance in Parkinson Disease.
Article in Archives of physical medicine and rehabilitation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Clinical Validation of Pupil Response During Walking in Parkinson's Disease.Sensors (Basel, Switzerland) · 2026Article
- Slowed Driving Reaction Time in Preclinical Alzheimer's Disease.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2025Article
- Impairment in the behavioral control of body sway, gaze shift, and mental workload in Parkinson's disease.Scientific reports · 2025Article
- Can the Pupillary Light Reflex and Pupillary Unrest Be Used as Biomarkers of Parkinson's Disease? A Systematic Review and Meta-Analysis.Diagnostics (Basel, Switzerland) · 2025Review
- Article
- Cortical Correlates of Increased Postural Task Difficulty in Young Adults: A Combined Pupillometry and EEG Study.Sensors (Basel, Switzerland) · 2022Article
- Challenging the Vestibular System Affects Gait Speed and Cognitive Workload in Chronic Mild Traumatic Brain Injury and Healthy Adults.Frontiers in neurology · 2022Article
- A Neuro-Computational Model for Discrete-Continuous Dual-Task Process.Frontiers in computational neuroscience · 2022Article
- Pupillary Response to Postural Demand in Parkinson's Disease.Frontiers in bioengineering and biotechnology · 2021Article
- Psychometric Properties of NASA-TLX and Index of Cognitive Activity as Measures of Cognitive Workload in Older Adults.Brain sciences · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo investigate the reliability and validity of pupillary response during dual-task balance conditions in individuals with Parkinson disease (PD).
designCross-sectional study.
settingUniversity of Kansas Medical Center Parkinson's Disease and Movement Disorder Center.
participantsParticipants (N=68) included individuals with PD (n=33) and healthy controls (n=35).
interventionsNot applicable.
main outcome measuresPupillary response was the main outcome measure that was measured during the following conditions: single-task balance eyes open, single-task balance eyes occluded, dual-task eyes open, and dual-task eyes occluded. After each condition, the National Aeronautics and Space Administration-Task Load Index (NASA-TLX) was administered to assess self-reported cognitive workload. To examine the test-retest reliability of the pupillary response, the conditions were administered twice for each individual within 2 hours. Intraclass correlation coefficients (ICC) were used to analyze the test-retest reliability of pupillary response in each condition for both groups. Pearson's r correlation was used to assess the convergent validity of pupillary response against the NASA-TLX.
resultsThe test-retest reliability was excellent for both groups in almost all conditions (ICC>0.75). There were no correlations between pupillary response and the NASA-TLX. However, increased mental demand (a subitem of the NASA-TLX) significantly correlated with increased pupillary response in individuals with PD (r=0.38; P=.03).
conclusionsPupillary response showed excellent test-retest reliability and validity during dual-task balance for individuals with PD and healthy controls. Overall, these results suggest that pupillary response represents a stable index of cognitive workload during dual-task balance in individuals with PD.
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Registered trials
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