ArticleJournal of endodontics2020
Progress and Challenges in Microengineering the Dental Pulp Vascular Microenvironment.
Article in Journal of endodontics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Influence of extracellular matrix scaffolds on histological outcomes of regenerative endodontics in experimental animal models: a systematic review.BMC oral health · 2024Pooled it
- Cell homing within endodontic hydrogels: A scoping review.The Japanese dental science review · 2026Review
- Hypomineralized Enamel Alters Trigeminal Sensory Afferent Architecture, Transcriptome, and Dental Injury Responses.bioRxiv : the preprint server for biology · 2026Article
- Strategies to Microengineer Vascularized, Mineralized, and Immunomodulatory Niches for Dental Regeneration.Journal of endodontics · 2026Article
- Dental Pulp Regeneration: A Comprehensive Review of Stem Cells, Biomaterials, and Bioactive Cues.Stem cell reviews and reports · 2026Review
- Bioengineered Teeth and Regenerative Strategies: Advances in Tissue Engineering and Stem Cell Applications.Annals of biomedical engineering · 2026Review
- A bioactive composite of freeze-dried stem cells, porous microcarriers, and fibrinogen-thrombin gel for dental pulp tissue engineering.American journal of stem cells · 2026Article
- A dual-scale micro/nanofibrous PLGA scaffold fabricated by co-electrospinning for regenerative endodontic procedures.Journal of applied oral science : revista FOB · 2026Article
- Self-assembly of differentiated dental pulp stem cells facilitates spheroid human dental organoid formation and prevascularization.World journal of stem cells · 2024Article
- A Systematic Review on Organ-on-a-Chip in PDMS or Hydrogel in Dentistry: An Update of the Literature.Gels (Basel, Switzerland) · 2024Review
- Advancing Dentistry through Bioprinting: Personalization of Oral Tissues.Journal of functional biomaterials · 2023Review
- High-Throughput Bioprinting of Geometrically-Controlled Pre-Vascularized Injectable Microgels for Accelerated Tissue Regeneration.Advanced healthcare materials · 2023Article
- Polyvinylpyrrolidone-Alginate-Carbonate Hydroxyapatite Porous Composites for Dental Applications.Materials (Basel, Switzerland) · 2023Article
- In vitro, ex vivo, and in vivo models for dental pulp regeneration.Journal of materials science. Materials in medicine · 2023Review
- The comprehensive on-demand 3D bio-printing for composite reconstruction of mandibular defects.Maxillofacial plastic and reconstructive surgery · 2022Review
- In-vitro models of biocompatibility testing for restorative dental materials: From 2D cultures to organs on-a-chip.Acta biomaterialia · 2022Review
- Oral mucosa equivalents, prevascularization approaches, and potential applications.Connective tissue research · 2022Review
- Biomaterial scaffolds for clinical procedures in endodontic regeneration.Bioactive materials · 2022Article
- Bioprinting of Complex Multicellular Organs with Advanced Functionality-Recent Progress and Challenges Ahead.Advanced materials (Deerfield Beach, Fla.) · 2022Review
- The Four Pillars for Successful Regenerative Therapy in Endodontics: Stem Cells, Biomaterials, Growth Factors, and Their Synergistic Interactions.Stem cells international · 2022Review
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
introductionThe dental pulp is highly vascularized and innervated tissue that is uniquely designed, being highly biologically active, while being enclosed within the calcified structure of the tooth. It is well-established that the dental pulp vasculature is a key requirement for the functional performance of the tooth. Therefore, controlled regeneration of the dental pulp vasculature is a challenge that must be met for future regenerative endeavors in endodontics.
methodsIn this perspective review, we address recent progress and challenges on the use of microengineering methods and biomaterials scaffolds to fabricate the dental pulp vascular microenvironment.
resultsThe conditions required to control the growth and differentiation of vascular capillaries are discussed, together with the conditions required for the formation of mature and stable pericyte-supported microvascular networks in 3-dimensional hydrogels and fabricated microchannels. Recent biofabrication methods, such as 3-dimensional bioprinting and micromolding are also discussed. Moreover, recent advances in the field of organs-on-a-chip are discussed regarding their applicability to dental research and endodontic regeneration.
conclusionCollectively, this short review offers future directions in the field that are presented with the objective of pointing toward successful pathways for successful clinical and translational strategies in regenerative endodontics, with especial emphasis on the dental pulp vasculature.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.