Evidence map›Paper›PMID 32950075›Full record

Observational studyThe Lancet. Public health2020

Hospital admissions for acute myocardial infarction before and after lockdown according to regional prevalence of COVID-19 and patient profile in France: a registry study.

Jules Mesnier, Yves Cottin, Pierre Coste, Emile Ferrari, François Schiele, Gilles Lemesle, Christophe Thuaire, Denis Angoulvant, Guillaume Cayla, Claire Bouleti and 18 more

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in The Lancet. Public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04050956 (French Cohort of Myocardial Infarction Evaluation), which is not on this map. Cited by 136 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
136citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04050956 recruitingnot on this map

French Cohort of Myocardial Infarction Evaluation

TypeobservationalSponsorAssistance Publique - Hôpitaux de ParisRan2019 to 2049Enrolled30,000ConditionsAcute Myocardial Infarction
3 · Its place in the literature

Who cites it

136 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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  11. Drivers and recent trends of hospitalisation costs related to acute pulmonary embolism.Clinical research in cardiology : official journal of the German Cardiac Society · 2025
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76 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

28 authors.

Jules MesnierDepartment of Cardiology, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris (AP-HP), Université de Paris, Paris, France; French Alliance for Cardiovascular Trials, Paris, France.
Yves CottinDepartment of Cardiology, Hôpital du Bocage, Physiopathologie et Epidémiologie Cérébro-Cardiovasculaires, Université de Bourgogne-Franche Comté, Dijon, France.
Pierre CosteHôpital Cardiologique, Université de Bordeaux, Bordeaux, France.
Emile FerrariDepartment of Cardiology, Hôpital Pasteur, Université de Nice, Nice, France.
François SchieleDepartment of Cardiology, Hôpital Jean Minjoz, Université de Bourgogne-Franche-Comté, Besançon, France.
Gilles LemesleFrench Alliance for Cardiovascular Trials, Paris, France; Institut Cœur Poumon, Centre Hospitalier Universitaire de Lille, Lille, France; Faculté de Médecine de Lille, Université de Lille, Lille, France; Institut Pasteur de Lille, Institut National de la Santé et de la Recherche Médicale (INSERM) U1011, Lille, France.
Christophe ThuaireDepartment of Cardiology, Hôpital Louis Pasteur, Centre Hospitalier de Chartres, Chartres, France.
Denis AngoulvantDepartment of Cardiology, Hôpital Trousseau, Centre Hospitalier Régional Universitaire de Tours, Tours, France; Transplantation, Immunology and Inflammation (T2i), Loire Valley Cardiovascular Collaboration, University of Tours, Tours, France.
Guillaume CaylaDepartment of Cardiology, Centre Hospitalier Universitaire Nimes, Montpellier University, Nimes, France.
Claire BouletiUniversité de Poitiers, Centre d'Investigation Clinique INSERM 1402, Department of Cardiology, Poitiers University Hospital, Poitiers, France.
Romain Gallet de Saint AurinDepartment of Cardiology, Henri Mondor University Hospital, AP-HP, Créteil, France.
Pascal GoubeDepartment of Cardiology, Centre Hospitalier Sud Francilien, Corbeil Essonne, France.
Thibault LhermusierDepartment of Cardiology, Centre Hospitalier Universitaire Toulouse Rangueil, Toulouse, France.
Jean-Guillaume DillingerDepartment of Cardiology, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris (AP-HP), Université de Paris, Paris, France.
Franck PaganelliDepartment of Cardiology, Hôpital Nord, Marseille, France.
Anis SaibDepartment of Cardiology, Groupe Hospitalier Intercommunal le Raincy Montfermeil, Montfermeil, France.
Fabrice PrunierInstitut MitoVasc, Centre National de la Recherche Scientifique Unités Mixtes de Recherche 6015 INSERM U1083, Université d'Angers, Service de Cardiologie, Centre Hospitalier Universitaire Angers, Angers, France.
Gerald VanzettoUrgences & Soins Intensifs Cardiologiques, Laboratoire Radiopharmaceutiques Biocliniques INSERM 1039, Centre Hospitalier Universitaire Grenoble Alpes, Grenoble, France.
Olivier DubreuilDepartment of Cardiology, Centre Hospitalier St Joseph et St Luc, Lyon, France.
Etienne PuymiratDepartment of Cardiology, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris (AP-HP), Université de Paris, Paris, France; French Alliance for Cardiovascular Trials, Paris, France.
Franck BoccaraAP-HP, Hôpitaux de l'Est Parisien, Hôpital Saint-Antoine, Department of Cardiology, Sorbonne Université INSERM Unités Mixtes de Recherche S_938, Centre de Recherche Saint-Antoine, Paris, France.
Hélène EltchaninoffUniversité de Rouen Normandie, INSERM U1096, Rouen University Hospital, Department of Cardiology, Rouen, France.
Marine CachanadoFrench Alliance for Cardiovascular Trials, Paris, France; Department of Pharmacology and Unité de Recherche Clinique des Hôpitaux de l'Est Parisien, Hôpital St Antoine, Université Paris Sorbonne, Paris, France.
Alexandra RousseauFrench Alliance for Cardiovascular Trials, Paris, France; Department of Cardiology, Hôpital Trousseau, Centre Hospitalier Régional Universitaire de Tours, Tours, France; Department of Pharmacology and Unité de Recherche Clinique des Hôpitaux de l'Est Parisien, Hôpital St Antoine, Université Paris Sorbonne, Paris, France.
Elodie DrouetFrench Alliance for Cardiovascular Trials, Paris, France; Department of Pharmacology and Unité de Recherche Clinique des Hôpitaux de l'Est Parisien, Hôpital St Antoine, Université Paris Sorbonne, Paris, France.
Philippe-Gabriel StegDepartment of Cardiology, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris (AP-HP), Université de Paris, Paris, France; French Alliance for Cardiovascular Trials, Paris, France.
Tabassome SimonFrench Alliance for Cardiovascular Trials, Paris, France; Department of Pharmacology and Unité de Recherche Clinique des Hôpitaux de l'Est Parisien, Hôpital St Antoine, Université Paris Sorbonne, Paris, France.
Nicolas DanchinDepartment of Cardiology, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris (AP-HP), Université de Paris, Paris, France; French Alliance for Cardiovascular Trials, Paris, France. Electronic address: nicolasdanchin@yahoo.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe COVID-19 pandemic has had a profound effect on general health care. We aimed to evaluate the effect of a nationwide lockdown in France on admissions to hospital for acute myocardial infarction, by patient characteristics and regional prevalence of the pandemic.

methodsIn this registry study, we collected data from 21 centres participating in the ongoing French Cohort of Myocardial Infarction Evaluation (FRENCHIE) registry, which collects data from all patients admitted for ST segment elevation myocardial infarction (STEMI) or non-ST segment elevation myocardial infarction (NSTEMI) within 48 h of symptom onset. We analysed weekly hospital admissions over 8 weeks: the 4 weeks preceding the institution of the lockdown and the 4 weeks following lockdown. The primary outcome was the change in the number of hospital admissions for all types of acute myocardial infarction, NSTEMI, and STEMI between the 4 weeks before lockdown and the 4 weeks after lockdown. Comparisons between categorical variables were made using χ

findingsBetween Feb 17 and April 12, 2020, 1167 patients were consecutively admitted within 48 h of acute myocardial infarction (583 with STEMI, 584 with NSTEMI) and were included in the study. Admissions for acute myocardial infarction decreased between the periods before and after lockdown was instituted, from 686 before to 481 after lockdown (30% decrease; incidence rate ratio 0·69 [95% CI 0·51-0·70]). Admissions for STEMI decreased from 331 to 252 (24%; 0·72 [0·62-0·85]), and admissions for NSTEMI decreased from 355 to 229 (35%; 0·64 [0·55-0·76]) following institution of the lockdown, with similar trends according to sex, risk factors, and regional prevalence of hospital admissions for COVID-19.

interpretationA marked decrease in hospital admissions was observed following the lockdown, irrespective of patient characteristics and regional prevalence of COVID-19. Health authorities should be aware of these findings, in order to adapt their message if the COVID-19 pandemic persists or recurs, or in case of future major epidemics.

fundingRecherche Hospitalo-Universitaire en Santé iVasc.

Indexed as

AgedAged, 80 and overCohort StudiesCoronavirus InfectionsCOVID-19FemaleFranceHumansMaleMiddle AgedMyocardial InfarctionPandemicsPatient AdmissionPneumonia, ViralPrevalenceRegistries

Identifiers

PMID32950075
PMCPMC7498416

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