Evidence map›Paper›PMID 32950074›Full record

ArticleBiophysical journal2020

Four-State Model for Simulating Kinetic and Steady-State Voltage-Dependent Gating of Gap Junctions.

Mindaugas Snipas, Tadas Kraujalis, Kestutis Maciunas, Lina Kraujaliene, Lukas Gudaitis, Vytas K Verselis

Open access · bronzeAbstract read
In one paragraph

Article in Biophysical journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Variable expressivity in long QT syndrome type 2 rabbits defines a low threshold for therapeuticAmerican journal of physiology. Heart and circulatory physiology · 2026
    Article
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Mindaugas SnipasInstitute of Cardiology, Lithuanian University of Health Sciences, Kaunas, Lithuania; Department of Mathematical Modelling, Kaunas University of Technology, Kaunas, Lithuania. Electronic address: minsnip@ktu.lt.
Tadas KraujalisInstitute of Cardiology, Lithuanian University of Health Sciences, Kaunas, Lithuania; Department of Applied Informatics, Kaunas University of Technology, Kaunas, Lithuania.
Kestutis MaciunasInstitute of Cardiology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Lina KraujalieneInstitute of Cardiology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Lukas GudaitisInstitute of Cardiology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Vytas K VerselisInstitute of Cardiology, Lithuanian University of Health Sciences, Kaunas, Lithuania; Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, New York, New York.
Lithuanian University of Health Sciences · LTAlbert Einstein College of Medicine · US

Funding

MECHANISMS OF GATING AND PERMEATION IN GAP JUNCTIONSR01GM054179 · NIGMS · YESHIVA UNIVERSITY · PI VERSELIS, VYTAUTAS K · 1996 to 2018
$5.3M
NIGMS NIH HHS R01 GM054179
6 · The paper itself

Abstract

Gap junction (GJ) channels, formed of connexin (Cx) proteins, provide a direct pathway for metabolic and electrical cell-to-cell communication. These specialized channels are not just passive conduits for the passage of ions and metabolites but have been shown to gate robustly in response to transjunctional voltage, V

Indexed as

Gap JunctionsIon Channel GatingConnexinsIon ChannelsKineticsConnexinsIon Channels

Identifiers

PMID32950074
PMCPMC7642245
OpenAlexW3082595104

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.