ArticleBMC biology2020
Inter-embryo gene expression variability recapitulates the hourglass pattern of evo-devo.
Article in BMC biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Internalized Evolutionary Inertia on Body Plan Evolution.Evolution & development · 2026Review
- Inter-individual gene expression variability implies stable regulation of brain-biased genes across organs in three ray-finned fishes.bioRxiv : the preprint server for biology · 2026Article
- Toward mechanisms underlying the developmental hourglass: evolvability and phylotypic conservation.EvoDevo · 2025Review
- Highly expressed cell wall genes contribute to robustness of sepal size.Plant signaling & behavior · 2025Article
- Super RNA Pol II domains enhance minor ZGA through 3D interaction to ensure the integrity of major transcriptional waves in late-ZGA mammals.Cell genomics · 2025Article
- Embryonic thermal environments drive plasticity in gene expression.Fish physiology and biochemistry · 2025Article
- Mayfly developmental atlas: developmental temporal expression atlas of the mayfly, Ephemera vulgata, reveals short germ-specific hox gene activation.BMC genomics · 2024Article
- Developmental hourglass: Verification by numerical evolution and elucidation by dynamical-systems theory.PLoS computational biology · 2024Article
- oggmap: a Python package to extract gene ages per orthogroup and link them with single-cell RNA data.Bioinformatics (Oxford, England) · 2023Article
- Viruses in LaboratoryViruses · 2023Article
- Continuous transcriptome analysis reveals novel patterns of early gene expression inCell genomics · 2023Article
- Transcriptional regulation underlying the temperature response of embryonic development rate in the winter moth.Molecular ecology · 2022Article
- Rhythmicity is linked to expression cost at the protein level but to expression precision at the mRNA level.PLoS computational biology · 2022Article
- Potential contribution of intrinsic developmental stability toward body plan conservation.BMC biology · 2022Article
- Article
- The hourglass model of evolutionary conservation during embryogenesis extends to developmental enhancers with signatures of positive selection.Genome research · 2021Article
- New Genes Born-In or Invading Vertebrate Genomes.Frontiers in cell and developmental biology · 2021Review
- Robust inference of positive selection on regulatory sequences in the human brain.Science advances · 2020Article
- Inter-embryo gene expression variability recapitulates the hourglass pattern of evo-devo.BMC biology · 2020Article
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Authors and funding
5 authors.
Funding
Abstract
backgroundThe evolution of embryological development has long been characterized by deep conservation. In animal development, the phylotypic stage in mid-embryogenesis is more conserved than either early or late stages among species within the same phylum. Hypotheses to explain this hourglass pattern have focused on purifying the selection of gene regulation. Here, we propose an alternative-genes are regulated in different ways at different stages and have different intrinsic capacities to respond to perturbations on gene expression.
resultsTo eliminate the influence of natural selection, we quantified the expression variability of isogenetic single embryo transcriptomes throughout fly Drosophila melanogaster embryogenesis. We found that the expression variability is lower at the phylotypic stage, supporting that the underlying regulatory architecture in this stage is more robust to stochastic variation on gene expression. We present evidence that the phylotypic stage is also robust to genetic variations on gene expression. Moreover, chromatin regulation appears to play a key role in the variation and evolution of gene expression.
conclusionsWe suggest that a phylum-level pattern of embryonic conservation can be explained by the intrinsic difference of gene regulatory mechanisms in different stages.
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