Depressogenic self-schemas are associated with smaller regional grey matter volume in never-depressed preadolescents.

Pan Liu, Matthew R J Vandemeer, Marc F Joanisse, Deanna M Barch, David J A Dozois, Elizabeth P Hayden

Abstract read

In one paragraph

Article in NeuroImage. Clinical, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it

0cells of the map it votes in

5citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

Structural Brain Correlates of Childhood Inhibited Temperament: An ENIGMA-Anxiety Mega-Analysis.Journal of the American Academy of Child and Adolescent Psychiatry · 2026
Article
Trial-level ERPs predicted behavioral responses during self-referential processing in late childhood.Social cognitive and affective neuroscience · 2024
Article
Evaluating the relative predictive validity of measures of self-referential processing for depressive symptom severity.Frontiers in psychiatry · 2024
Article
Behavioral and ERP indices of self-schematic processing show differential associations with emerging symptoms of depression and social anxiety in late childhood: Evidence from a community-dwelling sample.Biological psychology · 2023
Article
The Mediating Role of Perceived Stress and Academic Procrastination between Physical Activity and Depressive Symptoms among Chinese College Students during the COVID-19 Pandemic.International journal of environmental research and public health · 2022
Article

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Pan LiuDepartment of Psychology, Western University, Westminster Hall, 361 Windermere Rd, London, ON N6G 2K3, Canada; The Brain and Mind Institute, Western University, Western Interdisciplinary Research Building, London, ON N6A 3K7, Canada. Electronic address: pliu261@gmail.com.

Matthew R J VandemeerDepartment of Psychology, Western University, Westminster Hall, 361 Windermere Rd, London, ON N6G 2K3, Canada; The Brain and Mind Institute, Western University, Western Interdisciplinary Research Building, London, ON N6A 3K7, Canada.

Marc F JoanisseDepartment of Psychology, Western University, Westminster Hall, 361 Windermere Rd, London, ON N6G 2K3, Canada; The Brain and Mind Institute, Western University, Western Interdisciplinary Research Building, London, ON N6A 3K7, Canada.

Deanna M BarchPsychological and Brain Sciences, Washington University in St. Louis, Campus Box 1125, 1 Brookings Drive, St. Louis, MO 63130, USA.

David J A DozoisDepartment of Psychology, Western University, Westminster Hall, 361 Windermere Rd, London, ON N6G 2K3, Canada.

Elizabeth P HaydenDepartment of Psychology, Western University, Westminster Hall, 361 Windermere Rd, London, ON N6G 2K3, Canada; The Brain and Mind Institute, Western University, Western Interdisciplinary Research Building, London, ON N6A 3K7, Canada.

Funding

CIHR MOP86458

6 · The paper itself

Abstract

Self-referential processing (i.e., self-schemas that guide processing of self-descriptive information) emerges early in youth, with deeper encoding of negative self-descriptors and/or shallower encoding of positive self-descriptors causally linked to depression. However, the relationship between depressogenic self-schemas and brain structure is unclear. We investigated associations between self-schemas and regional grey matter volume (GMV) in 84 never-depressed preadolescents oversampled for depression risk based on maternal depression history. Self-schemas were assessed using a Self-Referent Encoding Task (SRET) and regional GMV was indexed via voxel-based morphometry analysis of structural magnetic resonance imaging data. Youths' positive self-schemas were associated with greater regional GMV within the ventrolateral prefrontal cortex (vlPFC) and posterior cingulate cortex (PCC), while negative self-schemas were associated with smaller regional GMV within vlPFC and PCC, areas important to emotion regulation and self-referential processing. These associations remained significant after controlling for youths' concurrent depressive symptoms. Exploratory mediation analysis suggested that adolescents' depressogenic self-schemas may mediate associations between GMV and depressive symptoms. Our findings suggest that the observed GMV variations within vlPFC and PCC may serve as neurobiological markers of depressogenic self-schemas during preadolescence.

Indexed as

Cerebral CortexGray MatterAdolescentBrainChildGyrus CinguliHumansMagnetic Resonance ImagingCognitive vulnerabilityDepressionGrey matter volumePreadolescentSelf-referent encoding tasksMRI

Identifiers

PMID32949875

DOI10.1016/j.nicl.2020.102422

PMCPMC7502366

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.