ArticleNeuroImage2021
Common and distinct neural substrates of sentence production and comprehension.
Article in NeuroImage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01927302 (The Center for the Neurobiology of Language Recovery), which is not on this map. Cited by 32 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Center for the Neurobiology of Language Recovery (CNLR)
Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Neurofunctional Correlates of Morphosyntactic and Thematic Impairments in Aphasia: A Systematic Review and Meta-analysis.Neuropsychology review · 2025Pooled it
- Speech and language impairments in behavioral variant frontotemporal dementia: A systematic review.Neuroscience and biobehavioral reviews · 2021Pooled it
- A cortical gradient in area 55b links language and somato-cognitive action networks.Research square · 2026Article
- Anterior temporal lobe, word comprehension, and physiology of atrophy in semantic primary progressive aphasia.Neurocase · 2025Article
- Fixel-Based White Matter Correlates of Sentence Comprehension in Post-Stroke Aphasia.Brain sciences · 2025Article
- Relationship between grammar and schizophrenia: a systematic review and meta-analysis.Communications medicine · 2025Article
- Decoding words during sentence production with ECoG reveals syntactic role encoding and structure-dependent temporal dynamics.Communications psychology · 2025Article
- Distinct neural correlates of morphosyntactic and thematic comprehension processes in aphasia.Brain communications · 2025Article
- Temporoparietal brain structures support sentence processing across the adult lifespan.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Functional Roles of Sensorimotor Alpha and Beta Oscillations in Overt Speech Production.bioRxiv : the preprint server for biology · 2024Article
- Neural basis of speech and grammar symptoms in non-fluent variant primary progressive aphasia spectrum.Brain : a journal of neurology · 2024Article
- Neural mechanisms of sentence production: a volumetric study of primary progressive aphasia.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Dissociating reading and auditory comprehension in persons with aphasia.Brain communications · 2024Article
- Brain-wide functional connectivity alterations and their cognitive correlates in subjective cognitive decline.Frontiers in neuroscience · 2024Article
- Verbal working memory and syntactic comprehension segregate into the dorsal and ventral streams, respectively.Brain communications · 2024Article
- Mapping sentence comprehension and syntactic complexity: evidence from 131 stroke survivors.Brain communications · 2024Article
- Causal evidence for a coordinated temporal interplay within the language network.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Using predictive validity to compare associations between brain damage and behavior.Human brain mapping · 2023Article
- Intraoperative cortical localization of music and language reveals signatures of structural complexity in posterior temporal cortex.iScience · 2023Article
- Early Subacute White Matter Hyperintensities and Recovery of Language After Stroke.Neurorehabilitation and neural repair · 2023Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Functional neuroimaging and lesion-symptom mapping investigations implicate a left frontal-temporal-parietal network for sentence processing. The majority of studies have focused on sentence comprehension, with fewer in the domain of sentence production, which have not fully elucidated overlapping and/or unique brain structures associated with the two domains, particularly for sentences with noncanonical word order. Using voxel-based lesion symptom mapping (VLSM) we examined the relationship between lesions within the left hemisphere language network and both sentence comprehension and production of simple and complex syntactic structures in 76 participants with chronic stroke-induced aphasia. Results revealed shared regions across domains in the anterior and posterior superior temporal gyri (aSTG, pSTG), and the temporal pole (adjusted for verb production/comprehension). Additionally, comprehension was associated with lesions in the anterior and posterior middle temporal gyri (aMTG, pMTG), the MTG temporooccipital regions, SMG/AG, central and parietal operculum, and the insula. Subsequent VLSM analyses (production versus comprehension) revealed critical regions associated with each domain: anterior temporal lesions were associated with production; posterior temporo-parietal lesions were associated with comprehension, implicating important roles for regions within the ventral and dorsal stream processing routes, respectively. Processing of syntactically complex, noncanonical (adjusted for canonical), sentences was associated with damage to the pSTG across domains, with additional damage to the pMTG and IPL associated with impaired sentence comprehension, suggesting that the pSTG is crucial for computing noncanonical sentences across domains and that the pMTG, and IPL are necessary for re-analysis of thematic roles as required for resolution of long-distance dependencies. These findings converge with previous studies and extend our knowledge of the neural mechanisms of sentence comprehension to production, highlighting critical regions associated with both domains, and further address the mechanism engaged for syntactic computation, controlled for the contribution of verb processing.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.