ArticleMicrovascular research2021
Nailfold capillaroscopy findings in patients with coronavirus disease 2019: Broadening the spectrum of COVID-19 microvascular involvement.
Article in Microvascular research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 86 citations in OpenAlex.
- Folic Acid and Endothelial Dysfunction in COVID-19.Life (Basel, Switzerland) · 2026Review
- Microcirculatory impairment and increased arterial stiffness in pediatric Long COVID patients.European journal of pediatrics · 2026Article
- A Perspective on the Role of Metformin in Treating Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Long COVID.ACS pharmacology & translational science · 2025Review
- Multicentre retrospective detection of nailfold videocapillaroscopy abnormalities in long covid patients.RMD open · 2025Observational
- Vascular Pathogenesis in Acute and Long COVID: Current Insights and Therapeutic Outlook.Seminars in thrombosis and hemostasis · 2025Review
- A Window into the Vascular Endothelium in Covid-19: Nails.Dermatology practical & conceptual · 2025Article
- Microvascular changes in children with MIS-C: a monocentric exploratory study using comparative nailfold capillaroscopy.Frontiers in pediatrics · 2025Article
- YOLOv8-Based System for Nail Capillary Detection on a Single-Board Computer.Diagnostics (Basel, Switzerland) · 2024Article
- Evaluation of Oxidative Stress and Endothelial Dysfunction in COVID-19 Patients.Medicina (Kaunas, Lithuania) · 2024Article
- Vascular Alterations Following COVID-19 Infection: A Comprehensive Literature Review.Life (Basel, Switzerland) · 2024Review
- Clinical characteristics and disease course before and after SARS-CoV-2 infection in a large cohort of systemic sclerosis patients.Turkish journal of medical sciences · 2024Article
- Automatic assessment of nailfold capillaroscopy software: a pilot study.Reumatologia · 2024Article
- Recurring SARS-CoV-2 variants: an update on post-pandemic, co-infections and immune response.Nanotheranostics · 2024Review
- Post-COVID exercise intolerance is associated with capillary alterations and immune dysregulations in skeletal muscles.Acta neuropathologica communications · 2023Article
- Onychomadesis in a COVID-19 patient.Wiener medizinische Wochenschrift (1946) · 2023Article
- Microvascular Alteration in COVID-19 Documented by Nailfold Capillaroscopy.Diagnostics (Basel, Switzerland) · 2023Review
- Nailfold Videocapillaroscopic Alterations as Markers of Microangiopathy in COVID-19 Patients.Journal of clinical medicine · 2023Article
- Host-Based Treatments for Severe COVID-19.Current issues in molecular biology · 2023Review
- Assessment of Blood Microcirculation Changes after COVID-19 Using Wearable Laser Doppler Flowmetry.Diagnostics (Basel, Switzerland) · 2023Article
- The effect of COVID-19 on development of hair and nail disorders: a Turkish multicenter, controlled study.International journal of dermatology · 2023Article
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Authors and funding
18 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveIncreasing evidence points to endothelial dysfunction as a key pathophysiological factor in coronavirus disease-2019 (COVID-19). No specific methods have been identified to predict, detect and quantify the microvascular alterations during COVID-19. Our aim was to assess microvasculature through nailfold videocapillaroscopy (NVC) in COVID-19 patients.
methodsWe performed NVC in patients with a confirmed diagnosis of COVID-19 pneumonia. Elementary alterations were reported for each finger according to a semi-quantitative score. Capillary density, number of enlarged and giant capillaries, number of micro-hemorrhages and micro-thrombosis (NEMO score) were registered.
resultsWe enrolled 82 patients (mean age 58.8 ± 13.2 years, male 68.3%) of whom 28 during the hospitalization and 54 after recovery and hospital discharge. At NVC examination we found abnormalities classifiable as non-specific pattern in 53 patients (64.6%). Common abnormalities were pericapillary edema (80.5%), enlarged capillaries (61.0%), sludge flow (53.7%), meandering capillaries and reduced capillary density (50.0%). No pictures suggestive of scleroderma pattern have been observed. Acute COVID-19 patients, compared to recovered patients, showed a higher prevalence of hemosiderin deposits as a result of micro-hemorrhages (P = .027) and micro-thrombosis (P < .016), sludge flow (P = .001), and pericapillary edema (P < .001), while recovered patients showed a higher prevalence of enlarged capillaries (P < .001), loss of capillaries (P = .002), meandering capillaries (P < .001), and empty dermal papillae (P = .006).
conclusionCOVID-19 patients present microvascular abnormalities at NVC. Currently ill and recovered subjects are characterized by a different distribution of elementary capillaroscopic alterations, resembling acute and post-acute microvascular damage. Further studies are needed to assess the clinical relevance of NVC in COVID-19.
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