ReviewEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2021
Lumbar interbody fusion: recent advances in surgical techniques and bone healing strategies.
Review in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
84 citing papers in PubMed, 4 syntheses or guidelines pooled it, 135 citations in OpenAlex.
- Short-term clinical efficacy and safety of unilateral biportal endoscopic transforaminal lumbar interbody fusion versus minimally invasive transforaminal lumbar interbody fusion in the treatment of lumbar degenerative diseases: a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2023Pooled it
- The efficacy of thoracolumbar interfascial plane block for lumbar spinal surgeries: a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2023Pooled it
- Is unilateral pedicle screw fixation as effective as bilateral pedicle screw fixation in transforaminal lumbar interbody fusion: a meta-analysis of randomized controlled trials.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2023Pooled it
- Minimally invasive transforaminal lumbar interbody fusion versus oblique lateral interbody fusion for lumbar degenerative disease: a meta-analysis.BMC musculoskeletal disorders · 2021Pooled it
- Evaluating the Efficacy of Water-Soluble Bone Wax (Tableau Wax) in Reducing Blood Loss in Spinal Fusion Surgery: A Randomized, Controlled, Pilot Study.Medicina (Kaunas, Lithuania) · 2023Trial
- Hounsfield unit threshold to predict lumbar fusion failure: a finite element study.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2026Article
- Comparison of unilateral biportal endoscopic lumbar interbody fusion (UBE-LIF) and conventional open TLIF in degenerative lumbar spine disease: a radiological, clinical, and laboratory study.Journal of orthopaedic surgery and research · 2026Article
- Design of 3D-printed hydroxyapatite intervertebral fusion cages in a patient specific framework.Medical & biological engineering & computing · 2026Article
- Clinical outcomes and radiologic parameters of percutaneous endoscopic posterior/transforaminal lumbar interbody fusion using rammed-earth technique.Frontiers in surgery · 2026Article
- Evaluation of bony fusion after posterior lumbar interbody fusion: a systematic review and meta-analysis.Brain & spine · 2026Review
- The role of lumbar core muscle morphology in residual chronic low back pain after PLIF: a retrospective analysis.Frontiers in surgery · 2026Article
- Residual bone mass after TLIF treated by TELD under local anesthesia: a case report.Frontiers in surgery · 2026Article
- Evaluation of the porosity and structural stability of 3D-printed porous titanium pedicle screws using finite element analysis.Biomedical engineering letters · 2026Article
- C-reactive protein to albumin ratio as a predictor of early postoperative wound complications in patients undergoing posterior lumbar spine surgery.Frontiers in surgery · 2026Article
- Development and validation of a predictive nomogram for cage migration after posterior lumbar interbody fusion: a retrospective study of 517 patients.Frontiers in surgery · 2026Article
- CT Evaluation of Lumbar Interbody Fusion: A Comprehensive Review with an Integrated Framework for Principle-Based Interpretation.Diagnostics (Basel, Switzerland) · 2026Review
- Comparison of clinical efficacy of modified transforaminal lumbar interbody fusion (M-TLIF) and posterior lumbar interbody fusion (PLIF) with bone cement-reinforced pedicle screws for osteoporosis combined with lumbar degenerative disease.European journal of medical research · 2025Article
- Risk factors for postoperative ileus following transforaminal lumbar interbody fusion: a retrospective study.Journal of orthopaedic surgery and research · 2025Article
- Comparison of learning curves and clinical efficacy of two endoscopic techniques for single segment lumbar degenerative disease.Scientific reports · 2025Article
- Research trends and clustering analysis of postoperative infections following lumbar interbody fusion: a bibliometric study.Neurosurgical review · 2025Article
24 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeLumbar interbody fusion (LIF) is a treatment option for low back pain secondary to lumbar instability and/or deformity. This review highlights recent studies of surgical techniques and bone healing strategies for LIF.
methodsRelevant articles were identified by searching the PubMed database from January 1948 to April 2020, with a focus on the last 5 years, using the following keywords: LIF approach, LIF cage, stem cells for LIF, biomaterials for LIF, and osteobiologics for LIF.
resultsLIF procedures were traditionally performed through either a posterior approach (PLIF), or an anterior approach. Later, the transforaminal LIF approach gained popularity over the PLIF as it entailed less nerve retraction. To minimize paraspinal muscle dissections, alternative approaches including lateral LIF, oblique LIF, and minimally invasive approaches have been developed and utilized. These modifications have improved the surgical outcomes of LIF. However, the most recent rates of non-union after LIF procedures still ranged from 7 to 20% with an even higher incidence in patients with osteoporosis. This review summarizes the advantages and disadvantages of each surgical approach and current efforts to enhance LIF by improving fusion cage material properties and developing novel osteobiologic products that contain nanomaterials for controlled release of effective osteogenic proteins and mesenchymal stem cells.
conclusionsThere have been significant advances in surgical technologies for LIF over the past decades. Post-operative non-union remains a major challenge, which could be addressed by development of more effective surgical techniques, fusion cages, and bone healing products through joint efforts from spine surgeons, bone biologists, and material engineers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.