Evidence map›Paper›PMID 32949220›Full record

SynthesisNeurourology and urodynamics2020

Genetic variants and expression changes in urgency urinary incontinence: A systematic review.

Wilke M Post, Alejandra M Ruiz-Zapata, Hilde Grens, Rob B M de Vries, Geert Poelmans, Marieke J H Coenen, Dick A W Janssen, John P F A Heesakkers, Egbert Oosterwijk, Kirsten B Kluivers

Open access · hybridAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Neurourology and urodynamics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 5 pooled it
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 5 syntheses or guidelines pooled it, 12 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Wilke M PostDepartment of Obstetrics and Gynecology, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID 0000-0002-9126-0072
Alejandra M Ruiz-ZapataDepartment of Obstetrics and Gynecology, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID 0000-0002-7619-2139
Hilde GrensDepartment of Obstetrics and Gynecology, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID 0000-0002-8750-8338
Rob B M de VriesDepartment for Health Evidence, SYRCLE, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID 0000-0002-0000-8796
Geert PoelmansDepartment of Human Genetics, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID 0000-0001-7039-6985
Marieke J H CoenenDepartment of Human Genetics, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID 0000-0001-8796-2031
Dick A W JanssenDepartment of Urology, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID 0000-0002-5724-7464
John P F A HeesakkersDepartment of Urology, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID 0000-0003-1570-1945
Egbert OosterwijkDepartment of Urology, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID 0000-0001-5049-0018
Kirsten B KluiversDepartment of Obstetrics and Gynecology, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID 0000-0002-4681-4304
Radboud University Nijmegen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo perform a systematic review summarizing the knowledge of genetic variants, gene, and protein expression changes in humans and animals associated with urgency urinary incontinence (UUI) and to provide an overview of the known molecular mechanisms related to UUI.

methodsA systematic search was performed on March 2, 2020, in PubMed, Embase, Web of Science, and the Cochrane library. Retrieved studies were screened for eligibility. The risk of bias was assessed using the ROBINS-I (human) and SYRCLE (animal) tool. Data were presented in a structured manner and in the case of greater than five studies on a homogeneous outcome, a meta-analysis was performed.

resultsAltogether, a total of 10,785 records were screened of which 37 studies met the inclusion criteria. Notably, 24/37 studies scored medium-high to high on risk of bias, affecting the value of the included studies. The analysis of 70 unique genes and proteins and three genome-wide association studies showed that specific signal transduction pathways and inflammation are associated with UUI. A meta-analysis on the predictive value of urinary nerve growth factor (NGF) levels showed that increased urinary NGF levels correlate with UUI.

conclusionThe collective evidence showed the involvement of two molecular mechanisms (signal transduction and inflammation) and NGF in UUI, enhancing our understanding of the pathophysiology of UUI. Unfortunately, the risk of bias was medium-high to high for most studies and the value of many observations remains unclear. Future studies should focus on elucidating how deficits in the two identified molecular mechanisms contribute to UUI and should avoid bias.

Indexed as

Genetic VariationDysuriaGenome-Wide Association StudyHumansNerve Growth FactorUrinary Incontinence, UrgeNerve Growth Factorgene expression changesgenetic variantsprotein expression changesurgency urinary incontinence

Identifiers

PMID32949220
PMCPMC7692907
OpenAlexW3087069791

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.