Evidence map›Paper›PMID 32949216›Full record

ArticleBrain and behavior2020

Brain reactions to the use of sensorized hand prosthesis in amputees.

Giuseppe Granata, Riccardo Di Iorio, Francesca Miraglia, Massimo Caulo, Francesco Iodice, Fabrizio Vecchio, Giacomo Valle, Ivo Strauss, Edoardo D'anna, Francesco Iberite and 7 more

Open access · goldAbstract read
In one paragraph

Article in Brain and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Functional and Structural Neural Plasticity Following sEMG Control of a Virtual Prosthetic Hand in an Individual with Bilateral Upper-Limb Congenital Amputation.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2025
    Article
  3. Cortical Reorganization after Limb Loss: Bridging the Gap between Basic Science and Clinical Recovery.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 3 countries.

Giuseppe GranataInstitute of Neurology, Fondazione Policlinico A. Gemelli-IRCCS, Roma, Italy.ORCID 0000-0002-8939-7467
Riccardo Di IorioInstitute of Neurology, Fondazione Policlinico A. Gemelli-IRCCS, Roma, Italy.
Francesca MiragliaDepartment of Neuroscience & Rehabilitation, IRCCS San Raffaele Pisana, Roma, Italy.ORCID 0000-0002-4642-3952
Massimo CauloDepartment of Neuroscience and Imaging and ITAB-Institute of Advanced Biomedical Technologies, University G. d'Annunzio, Chieti, Italy.
Francesco IodiceInstitute of Neurology, Fondazione Policlinico A. Gemelli-IRCCS, Roma, Italy.
Fabrizio VecchioDepartment of Neuroscience & Rehabilitation, IRCCS San Raffaele Pisana, Roma, Italy.
Giacomo ValleThe BioRobotics Institute and Department of Excellence in Robotics and AI, Scuola Superiore Sant'Anna, Pisa, Italy.ORCID 0000-0002-2637-8007
Ivo StraussThe BioRobotics Institute and Department of Excellence in Robotics and AI, Scuola Superiore Sant'Anna, Pisa, Italy.
Edoardo D'annaCenter for Neuroprosthetics and Institute of Bioengineering, School of Engineering, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Francesco IberiteThe BioRobotics Institute and Department of Excellence in Robotics and AI, Scuola Superiore Sant'Anna, Pisa, Italy.ORCID 0000-0002-4365-5328
Liverana LaurettiInstitute of Neurosurgery, Fondazione Policlinico A. Gemelli-IRCCS, Roma, Italy.
Eduardo FernandezInstitute of Neurology, Fondazione Policlinico A. Gemelli-IRCCS, Roma, Italy.
Roberto RomanelloInstitute of Neurology, Fondazione Policlinico A. Gemelli-IRCCS, Roma, Italy.
Francesco M PetriniCenter for Neuroprosthetics and Institute of Bioengineering, School of Engineering, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Stanisa RaspopovicCenter for Neuroprosthetics and Institute of Bioengineering, School of Engineering, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Silvestro MiceraThe BioRobotics Institute and Department of Excellence in Robotics and AI, Scuola Superiore Sant'Anna, Pisa, Italy.ORCID 0000-0003-4396-8217
Paolo M RossiniDepartment of Neuroscience & Rehabilitation, IRCCS San Raffaele Pisana, Roma, Italy.
Agostino Gemelli University Polyclinic · ITScuola Superiore Sant'Anna · ITETH Zurich · CHIRCCS Ospedale San Raffaele · ITÉcole Polytechnique Fédérale de Lausanne · CHUniversità Cattolica del Sacro Cuore · ITUniversity of Chieti-Pescara · IT

Funding

FET Proactive: Evolving Living Technologies FP7-ICT-2013Natural sensory feedback for phantom limb pain modulation and therapyNeurocontrolled Bidirectional Artificial upper limb and hand prosthesis 611687NEurocontrolled MEchatronic prostheSISPartly funded by the Bertarelli Foundation, the Swiss National Competence Center Research (NCCR) Robotics, and by the CHRONOS project funded by the Swiss National Science Foundation
6 · The paper itself

Abstract

objectiveWe investigated for the first time the presence of chronic changes in the functional organization of sensorimotor brain areas induced by prolonged training with a bidirectional hand prosthesis.

methodsA multimodal neurophysiological and neuroimaging evaluation of brain functional changes occurring during training in five consecutive amputees participating to experimental trials with robotic hands over a period of 10 years was carried out. In particular, modifications to the functional anatomy of sensorimotor brain areas under resting conditions were explored in order to check for eventual changes with respect to baseline.

resultsFull evidence is provided to demonstrate brain functional changes, and some of them in both the hemispheres and others restricted to the hemisphere contralateral to the amputation/prosthetic hand.

conclusionsThe study describes a unique experimental experience showing that brain reactions to the prolonged use of an artificial hand can be tracked for a tailored approach to a fully embedded artificial upper limb for future chronic uses in daily activities.

Indexed as

AmputeesArtificial LimbsAmputation, SurgicalHandHumansUpper Extremityadvanced biotechnologiesbrain functionhand prosthesispersonalized medicine

Identifiers

PMID32949216
PMCPMC7667362
OpenAlexW3087276359

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.