Evidence map›Paper›PMID 32949099›Full record

ArticleMolecular oncology2021

Defining the dimensions of circulating tumor cells in a large series of breast, prostate, colon, and bladder cancer patients.

Pauline A J Mendelaar, Jaco Kraan, Mai Van, Leonie L Zeune, Leon W M M Terstappen, Esther Oomen-de Hoop, John W M Martens, Stefan Sleijfer

Abstract read
In one paragraph

Article in Molecular oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

  1. Article
  2. Liquid biopsy in bladder cancer: towards precision oncology.Journal of translational medicine · 2026
    Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Role of circulating tumor cell clusters in breast cancer.Translational breast cancer research : a journal focusing on translational research in breast cancer · 2026
    Review
  13. Circulating Tumor Cells for the Monitoring of Lung Cancer Therapies.International journal of molecular sciences · 2025
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pauline A J MendelaarDepartment of Medical Oncology, Erasmus MC University Medical Center, Cancer Institute, Rotterdam, The Netherlands.ORCID 0000-0002-1496-9627
Jaco KraanDepartment of Medical Oncology, Erasmus MC University Medical Center, Cancer Institute, Rotterdam, The Netherlands.
Mai VanDepartment of Medical Oncology, Erasmus MC University Medical Center, Cancer Institute, Rotterdam, The Netherlands.
Leonie L ZeuneDepartment of Medical Cell BioPhysics, University of Twente, Enschede, The Netherlands.
Leon W M M TerstappenDepartment of Medical Cell BioPhysics, University of Twente, Enschede, The Netherlands.
Esther Oomen-de HoopDepartment of Medical Oncology, Erasmus MC University Medical Center, Cancer Institute, Rotterdam, The Netherlands.
John W M MartensDepartment of Medical Oncology, Erasmus MC University Medical Center, Cancer Institute, Rotterdam, The Netherlands.
Stefan SleijferDepartment of Medical Oncology, Erasmus MC University Medical Center, Cancer Institute, Rotterdam, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circulating tumor cells (CTCs) in the blood of cancer patients are of high clinical relevance. Since detection and isolation of CTCs often rely on cell dimensions, knowledge of their size is key. We analyzed the median CTC size in a large cohort of breast (BC), prostate (PC), colorectal (CRC), and bladder (BLC) cancer patients. Images of patient-derived CTCs acquired on cartridges of the FDA-cleared CellSearch

Indexed as

Breast NeoplasmsCell CountCell Line, TumorCell NucleusCell SizeCohort StudiesColonic NeoplasmsFemaleHumansIndolesKeratinsMaleNeoplastic Cells, CirculatingProstatic NeoplasmsUrinary Bladder NeoplasmsDAPIIndolesKeratinscell morphologycell sizecirculating tumor cellsmetastatic cancersingle cell isolation methods

Identifiers

PMID32949099
PMCPMC7782084

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.