Evidence map›Paper›PMID 32949093›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2021

Quantifying infection risks in incompatible living donor kidney transplant recipients.

Robin K Avery, Jennifer D Motter, Kyle R Jackson, Robert A Montgomery, Allan B Massie, Edward S Kraus, Kieren A Marr, Bonnie E Lonze, Nada Alachkar, Mary J Holechek and 11 more

Open access · hybridAbstract read
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Longitudinal assessment of the effect of invasive fungal infections on transplant success in kidney transplant recipients.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2025
    Article
  6. Article
  7. Article
  8. Imlifidase for Kidney Transplantation of Highly Sensitized Patients With a Positive Crossmatch: The French Consensus Guidelines.Transplant international : official journal of the European Society for Organ Transplantation · 2023
    Article
  9. Review
  10. Impact of Repeated Non-Fatal Infections on Quality of Life and Graft Function in ABO-Incompatible Kidney Transplants.Transplant infectious disease : an official journal of the Transplantation Society
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 4 institutions in 1 country.

Robin K AveryDivision of Infectious Disease, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.ORCID 0000-0001-7692-3619
Jennifer D MotterDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.ORCID 0000-0003-1750-0119
Kyle R JacksonDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.ORCID 0000-0002-8135-5377
Robert A MontgomeryThe NYU Transplant Institute, New York University Langone Medical Center, New York, New York.
Allan B MassieDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.ORCID 0000-0002-5288-5125
Edward S KrausDivision of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Kieren A MarrDivision of Infectious Disease, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Bonnie E LonzeThe NYU Transplant Institute, New York University Langone Medical Center, New York, New York.ORCID 0000-0002-0973-1657
Nada AlachkarDivision of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Mary J HolechekDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Darin OstranderDivision of Infectious Disease, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Niraj DesaiDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Madeleine M WaldramDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.ORCID 0000-0001-5706-4353
Shmuel ShohamDivision of Infectious Disease, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Seema Mehta SteinkeDivision of Infectious Disease, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Aruna SubramanianStanford University Medical Center, Stanford, California.
Janet M HillerDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Julie LangleeDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Sheila YoungDivision of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Dorry L SegevDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.ORCID 0000-0002-1924-4801
Jacqueline M Garonzik WangDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Johns Hopkins University · USNYU Langone Health · USNational Marrow Donor Program · USStanford Medicine · US

Funding

Quantifying Risk And Survival Benefit from Incompatible Kidney TransplantationR01DK098431 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SEGEV, DORRY L. · 2013 to 2017
$3.7M
Patient Oriented Research in Transplant and Oncology IDK24AI085118 · NIAID · JOHNS HOPKINS UNIVERSITY · PI MARR, KIEREN A. · 2010 to 2014
$995k
Patient Oriented Research in Solid Organ TransplantationK24AI144954 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SEGEV, DORRY L. · 2020 to 2024
$956k
Determinants of chronic kidney disease in African-American live kidney donorsK01DK101677 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI MASSIE, ALLAN B · 2015 to 2019
$789k
Aggressive Center Report Cards to Safely Increase Transplantation of Suboptimal KidneysK23DK115908 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI GARONZIK WANG, JACQUELINE M · 2018 to 2021
$516k
Differential Survival Benefit of Incompatible Living Donor Kidney Transplantation: Modeling Outcomes for Different Patient PhenotypesF32DK113719 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI JACKSON, KYLE R · 2017 to 2019
$238k
NIAID NIH HHS K24 AI085118NIAID NIH HHS K24 AI144954NIDDK NIH HHS F32 DK113719NIDDK NIH HHS K01 DK101677NIDDK NIH HHS K23 DK115908NIDDK NIH HHS R01 DK098431
6 · The paper itself

Abstract

Desensitization has enabled incompatible living donor kidney transplantation (ILDKT) across HLA/ABO barriers, but added immunomodulation might put patients at increased risk of infections. We studied 475 recipients from our center from 2010 to 2015, categorized by desensitization intensity: none/compatible (n = 260), low (0-4 plasmaphereses, n = 47), moderate (5-9, n = 74), and high (≥10, n = 94). The 1-year cumulative incidence of infection was 50.1%, 49.8%, 66.0%, and 73.5% for recipients who received none, low, moderate, and high-intensity desensitization (P < .001). The most common infections were UTI (33.5% of ILDKT vs. 21.5% compatible), opportunistic (21.9% vs. 10.8%), and bloodstream (19.1% vs. 5.4%) (P < .001). In weighted models, a trend toward increased risk was seen in low (wIRR =

Indexed as

Kidney TransplantationABO Blood-Group SystemBlood Group IncompatibilityGraft RejectionGraft SurvivalHumansLiving DonorsTransplant RecipientsABO Blood-Group Systemclinical research / practicedesensitizationinfection and infectious agentsinfectious diseasekidney transplantation: living donorkidney transplantation / nephrology

Identifiers

PMID32949093
PMCPMC7972996
OpenAlexW3087668436

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.