SynthesisCanadian journal of anaesthesia = Journal canadien d'anesthesie2020
Worldwide management of donors after neurological death: a systematic review and narrative synthesis of guidelines.
Synthesis in Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Exploring the challenges: main contraindications in organ donation in ColombiaBiomedica : revista del Instituto Nacional de Salud · 2026Article
- [Perioperative anesthesiological management of postmortem organ donors in Germany-A prospective cross-sectional study using an online survey].Die Anaesthesiologie · 2026Article
- Contemporary evidence to inform management of deceased potential thoracic organ donors after brain death.JHLT open · 2026Article
- Anesthetic Management of Brain-Dead Donors During Organ Retrieval: Hemodynamic Effects and Potential Organ-Protective Implications - A Retrospective Analysis of 85 Cases.Transplant international : official journal of the European Society for Organ Transplantation · 2026Article
- Management of adult organ donors after brain death in ICU: insights from an Italian survey.Journal of anesthesia, analgesia and critical care · 2025Article
- Relatives' and Intensive Care Unit Personnel's Perspectives of Care in Organ Donation: Protocol for a Multiple Methods Study.JMIR research protocols · 2024Article
- Activation of the Innate Immune System in Brain-Dead Donors Can Be Reduced by Luminal Intestinal Preservation During Organ Procurement Surgery - A Porcine Model.Transplant international : official journal of the European Society for Organ Transplantation · 2024Article
- Haemodynamic management in brain death donors: Influence of aetiology of brain death.World journal of transplantation · 2023Article
- Vasopressin Use in the Support of Organ Donors: Physiological Rationale and Review of the Literature.Critical care explorations · 2023Review
- Organ Donation after Damage Control Strategy in Trauma Patients: Experience from First Level Trauma Center in Italy.Life (Basel, Switzerland) · 2022Article
- Hemodynamic management in brain dead donors.World journal of transplantation · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe objectives of this study were to systematically identify and describe guidelines for the care of neurologically deceased donors and to evaluate their methodological quality, with the aim of informing and supporting the new Canadian guidelines for the management of organ donors. METHODOLOGY: Following a systematic search, we included any document endorsed by an organ donation organization, a professional society, or a government, that aims to direct the medical management of adult, neurologically deceased, multi-organ donors. We extracted recommendations pertaining to six domains: the autonomic storm, hemodynamic instability, hormone supplementation, ventilation, blood product transfusions, and general intensive care unit (ICU) care. Methodological quality of the guidelines was assessed by the validated AGREE-II tool. MAIN
findingsThis review includes 27 clinical practice guidelines representing 26 countries published between 1993 and 2019. Using the AGREE-II validated tool for the evaluation of guidelines' quality, documents generally scored well on their scope and clarity of presentation. Nevertheless, quality was limited in terms of the scientific rigor of guideline development. Recommendations varied substantially across the domains of managing the autonomic storm, subsequent management of hemodynamic instability, hormone therapy, mechanical ventilation, blood product transfusion, and general ICU care. We found consistent recommendations for low tidal volume ventilation subsequent to the publication of a landmark clinical trial.
conclusionHighly inconsistent recommendations for deceased donor care summarized in this review likely reflect the relatively slow emergence of high-quality clinical research in this field, as well as a late uptake of recent validated guideline methodology. Even in this context of few randomized-controlled trials, our group supported the need for new Canadian guidelines for the management of organ donors that follow rigorous recognized methodology and grading of the evidence.
trial registrationPROSPERO (CRD42018084012); registered 25 February 2016.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.