Evidence map›Paper›PMID 32948935›Full record

ReviewNeurochemical research2020

Reevaluation of Astrocyte-Neuron Energy Metabolism with Astrocyte Volume Fraction Correction: Impact on Cellular Glucose Oxidation Rates, Glutamate-Glutamine Cycle Energetics, Glycogen Levels and Utilization Rates vs. Exercising Muscle, and Na

Gerald A Dienel, Douglas L Rothman

Erratum issuedAbstract readReview
PubMed Publisher
In one paragraph

Review in Neurochemical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
  2. Review
  3. Mitochondrial CaBiomolecules · 2026
    Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Astroglial activation: Current concepts and future directions.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Review
  15. Insulin-stimulated brain glucose uptake correlates with brain metabolites in severe obesity: A combined neuroimaging study.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Gerald A DienelDepartment of Neurology, Mail Slot 500, University of Arkansas for Medical Sciences, 4301 W. Markham St., Little Rock, AR, 72205, USA. gadienel@uams.edu.ORCID http://orcid.org/0000-0001-8887-3057
Douglas L RothmanMagnetic Resonance Research Center and Department of Radiology, Yale University, New Haven, CT, 06520, USA.
University of New Mexico · USYale University · US

Funding

13C MRS Studies of Brain Mitochondrial Metabolism in Insulin ResistanceR01NS087568 · NINDS · YALE UNIVERSITY · PI PETERSEN, KITT F, ROTHMAN, DOUGLAS LYLE · 2014 to 2018
$2.1M
Validation of GABA MRS as a Biomarker of InhibitionR01MH109159 · NIMH · YALE UNIVERSITY · PI BEHAR, KEVIN L, ROTHMAN, DOUGLAS LYLE · 2016 to 2019
$1.7M
MRS validation of computational metabolic modeling of human brain function to determine energetic disruptions underlying fMRI-derived functional connectivity in degenerative or psychiatric disordersR01NS100106 · NINDS · YALE UNIVERSITY · PI HYDER, DEWAN SYED FAHMEED, ROTHMAN, DOUGLAS LYLE · 2017 to 2021
$959k
NIH HHS R01 MH109159NIH HHS R01 NS087568NIH HHS R01 NS100106NIMH NIH HHS R01 MH109159
6 · The paper itself

Abstract

Accurate quantification of cellular contributions to rates of substrate utilization in resting, activated, and diseased brain is essential for interpretation of data from studies using [

Indexed as

Cell SizeAnimalsAstrocytesBrainEnergy MetabolismGlucoseGlutamic AcidGlutamineGlycogenHumansMuscle, SkeletalNeuronsOxidation-ReductionGlucoseGlutamic AcidGlutamineGlycogenAstrocyteGlucose oxidationGlycogen metabolismNeuronSurface-to-volume ratioVolume fraction

Identifiers

PMID32948935
OpenAlexW3087174653

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.