ArticleEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2020
The importance of timely treatment for quality of life and survival in patients with symptomatic spinal metastases.
Article in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Radiofrequency Ablation of Painful Spinal Metastasis: A Systematic Review.Current oncology (Toronto, Ont.) · 2025Pooled it
- Enabling earlier detection of spinal lesions in CT imaging with artificial intelligence-a case study.Frontiers in artificial intelligence · 2026Article
- Adaptive-driven CT simulation-free multi-fraction SBRT radiotherapy: Initial clinical experience.Journal of applied clinical medical physics · 2025Article
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- Surgical management of spinal metastases: A cross-continental study in the United States and the Netherlands.Journal of bone oncology · 2025Article
- Radiotherapy and surgery: can this combination be further optimized for patients with metastatic spine disease?The oncologist · 2025Review
- Risk Factors for the Development of Neurological Deficits in Metastatic Spinal Disease: An International, Multicenter Delphi Study.Global spine journal · 2025Article
- Development of a natural language processing algorithm for the detection of spinal metastasis based on magnetic resonance imaging reports.North American Spine Society journal · 2024Article
- Adaptive-Driven CT Simulation-Free Soft Tissue Stereotactic Body Radiation Therapy: A Single-Patient Case Report.Cureus · 2024Article
- Characteristics and Outcome of Surgically Treated Patients with Intradural Extra- and Intramedullary Spinal Metastasis-A Single-Center Retrospective Case Series and Review.Current oncology (Toronto, Ont.) · 2024Review
- Clinical Characteristics, Surgical Outcomes, and Risk Factors for Emergency Surgery in Patients With Spinal Metastases: A Prospective Cohort Study.Neurospine · 2024Article
- Enhancing the referral process for surgical management of spinal metastases: insights from a 12-year, bi-institutional study of 533 patients.Frontiers in oncology · 2024Article
- The use of red flags during the referral chain of patients surgically treated for symptomatic spinal metastases.Neuro-oncology practice · 2023Article
- Time to Surgical Treatment for Metastatic Spinal Disease: Identification of Delay Intervals.Global spine journal · 2023Article
- Translation and validation of the Dutch Spine Oncology Study Group Outcomes Questionnaire (SOSGOQ2.0) to evaluate health-related quality of life in patients with symptomatic spinal metastases.BMC musculoskeletal disorders · 2022Article
- Costs Associated With Timely and Delayed Surgical Treatment of Spinal Metastases.Global spine journal · 2022Article
- Article
- Multidisciplinary Approach to Patients With Metastatic Spinal Cord Compression: A Diagnostic Therapeutic Algorithm to Improve the Neurological Outcome.Frontiers in oncology · 2022Article
- Letter to the Editor concerning "The importance of timely treatment for quality of life and survival in patients with symptomatic spinal metastases" by van Tol FR, et al. [Eur Spine J (2020): DOI 10.1007/s00586-020-06,599-x].European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2021Article
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6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeA major challenge in metastatic spinal disease is timely identification of patients. Left untreated, spinal metastases may lead to gross mechanical instability and/or neurological deficits, often requiring extensive invasive surgical treatment. The aim of this cohort study was to assess the correlation between delayed treatment of patients with spinal metastases and functional performance, quality of life and survival.
methodsAll patients surgically treated for metastatic spinal disease at a tertiary care facility were included for analysis. Patients who underwent elective surgery were considered as timely treated, whereas patients requiring emergency surgery were considered to be treated in a delayed fashion. EQ-5D scores, KPS scores and mortality rates were compared between the two groups.
resultsA total of 317 patients (215 timely treated, 102 delayed) had survivorship data available and 202 patients (147 timely treated, 55 delayed) had clinical data available. Multivariate analyses showed delayed treatment was associated with lower EQ-5D and KPS scores and higher mortality rates, independent of confounders such as baseline EQ-5D/KPS scores, neurological status, tumor prognosis and patient age.
conclusionsThe results from the present study show delayed treatment of patients with symptomatic spinal metastases has both direct and indirect adverse consequences for functional performance status, quality of life and survival. Optimization of referral pattern may accelerate the time to surgical treatment, potentially leading to better quality of life and survival.
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