ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2021
Structural and Functional Brain Abnormalities in Human Immunodeficiency Virus Disease Revealed by Multimodal Magnetic Resonance Imaging Fusion: Association With Cognitive Function.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Implications and prospects of immunological and neuroimaging research in HIV-associated neurocognitive disorders.Frontiers in neurologyPooled it
- Resting-state functional connectivity in HIV - Findings from the ENIGMA HIV working group.Psychiatry research. Neuroimaging · 2026Article
- Microglial reactivity and nodule formation are associated with Synaptodendritic damage in the brains of people with HIV-1.Brain pathology (Zurich, Switzerland) · 2026Article
- HIV-Associated Microstructural Abnormalities in Default Mode, Executive Control, and Salience Networks: Insights from Tensor-Valued Diffusion Encoding.Bioengineering (Basel, Switzerland) · 2026Article
- Diffusion tensor imaging-functional MRI fusion reveals disrupted white matter structure-function coupling in HIV-associated asymptomatic neurocognitive impairment.Frontiers in neuroscience · 2026Article
- Depressive disorders are associated with brain structural injury in HIV-positive men who have sex with men.BMC psychiatry · 2025Article
- HIV and Low Omega-3 Levels May Heighten Hippocampal Volume Differences Between Men and Women With Substance Use.Brain, behavior, & immunity - health · 2025Article
- Altered angular gyrus activation during the digit symbol substitution test in people living with HIV: beyond information processing speed deficits.Scientific reports · 2025Article
- The association between rapid antiretroviral therapy initiation and brain structure and function based on multimodal magnetic resonance imaging in HIV-positive men who have sex with men.BMC infectious diseases · 2025Article
- Brain injury, endocrine disruption, and immune dysregulation in HIV-positive men who have sex with men with late HIV diagnosis.Frontiers in immunology · 2025Article
- Functional and Structural Network Alterations in HIV-Associated Asymptomatic Neurocognitive Disorders: Evidence for Functional Disruptions Preceding Structural Changes.Neuropsychiatric disease and treatment · 2025Article
- Neuroimaging advances in neurocognitive disorders among HIV-infected individuals.Frontiers in neurology · 2025Review
- Cardiovascular Disease, Brain Glucose Metabolism, and Neurocognitive Decline in People With Human Immunodeficiency Virus.Open forum infectious diseases · 2024Article
- The differential effects of integrase strand transfer inhibitors and efavirenz on neuropsychiatric conditions and brain imaging in HIV-positive men who have sex with men.Biosafety and health · 2024Article
- Matrix-Variate Regression for Sparse, Low-Rank Estimation of Brain Connectivities Associated With a Clinical Outcome.IEEE transactions on bio-medical engineering · 2024Article
- Bridging brain and blood: a prospective view on neuroimaging-exosome correlations in HIV-associated neurocognitive disorders.Frontiers in neurology · 2024Review
- Brain function abnormalities and inflammation in HIV-positive men who have sex with men with depressive disorders.Frontiers in psychiatry · 2024Article
- Comparison of Resting State Functional Connectivity in Persons With and Without HIV: A Cross-sectional Study.The Journal of infectious diseases · 2023Article
- The Individualized Prediction of Neurocognitive Function in People Living With HIV Based on Clinical and Multimodal Connectome Data.IEEE journal of biomedical and health informatics · 2023Article
- Imaging of Brain Structural and Functional Effects in People With Human Immunodeficiency Virus.The Journal of infectious diseases · 2023Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundHuman immunodeficiency virus (HIV)-associated neurocognitive impairment remains a prevalent comorbidity that impacts daily functioning and increases morbidity. While HIV infection is known to cause widespread disruptions in the brain, different magnetic resonance imaging (MRI) modalities have not been effectively integrated. In this study, we applied 3-way supervised fusion to investigate how structural and functional coalterations affect cognitive function.
methodsParticipants (59 people living with HIV and 58 without HIV) completed comprehensive neuropsychological testing and multimodal MRI scanning to acquire high-resolution anatomical, diffusion-weighted, and resting-state functional images. Preprocessed data were reduced using voxel-based morphometry, probabilistic tractography, and regional homogeneity, respectively. We applied multimodal canonical correlation analysis with reference plus joint independent component analysis using global cognitive functioning as the reference.
resultsCompared with controls, participants living with HIV had lower global cognitive functioning. One joint component was both group discriminating and correlated with cognitive function. This component included the following covarying regions: fractional anisotropy in the corpus callosum, short and long association fiber tracts, and corticopontine fibers; gray matter volume in the thalamus, prefrontal cortex, precuneus, posterior parietal regions, and occipital lobe; and functional connectivity in frontoparietal and visual processing regions. Component loadings for fractional anisotropy also correlated with immunosuppression.
conclusionsThese results suggest that coalterations in brain structure and function can distinguish people with and without HIV and may drive cognitive impairment. As MRI becomes more commonplace in HIV care, multimodal fusion may provide neural biomarkers to support diagnosis and treatment of cognitive impairment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.