Evidence map›Paper›PMID 32948818›Full record

ArticleScientific reports2020

Pentagalloyl glucose from Schinus terebinthifolia inhibits growth of carbapenem-resistant Acinetobacter baumannii.

Micah Dettweiler, Lewis Marquez, Michelle Lin, Anne M Sweeney-Jones, Bhuwan Khatri Chhetri, Daniel V Zurawski, Julia Kubanek, Cassandra L Quave

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Anti-Amyloid Aggregation Effects of Gobaishi (Molecules (Basel, Switzerland) · 2025
    Article
  4. Potent Antifungal Activity of Penta-ACS infectious diseases · 2023
    Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Micah Dettweiler *Department of Dermatology, Emory University School of Medicine, Atlanta, GA, USA.
Lewis Marquez *Molecular and Systems Pharmacology Program, Emory University, Atlanta, GA, USA.
Michelle LinCenter for the Study of Human Health, Emory University, Atlanta, GA, USA.
Anne M Sweeney-JonesSchool of Chemistry and Biochemistry, Center for Microbial Dynamics and Infection, Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA.
Bhuwan Khatri ChhetriSchool of Chemistry and Biochemistry, Center for Microbial Dynamics and Infection, Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA.
Daniel V ZurawskiWound Infections Department, Bacterial Diseases Branch, Center for Infectious Disease Research, Walter Reed Army Institute of Research (WRAIR), Silver Spring, Maryland, USA.
Julia KubanekSchool of Chemistry and Biochemistry, Center for Microbial Dynamics and Infection, Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA.
Cassandra L QuaveDepartment of Dermatology, Emory University School of Medicine, Atlanta, GA, USA. cquave@emory.edu.
Emory University · USGeorgia Institute of Technology · USWalter Reed Army Institute of Research · US

Funding

The USP Center for Drug Discovery and ConservationU19TW007401 · FIC · GEORGIA INSTITUTE OF TECHNOLOGY · PI HAY, MARK E · 2014 to 2018
$5.3M
Novel compounds from botanical innovation yields Acinetobacter treatmentsR21AI136563 · NIAID · EMORY UNIVERSITY · PI QUAVE, CASSANDRA LEAH · 2018 to 2019
$443k
FIC NIH HHS U19 TW007401NIAID NIH HHS R21 AI136563
6 · The paper itself

Abstract

The rise of antibiotic resistance has necessitated a search for new antimicrobials with potent activity against multidrug-resistant gram-negative pathogens, such as carbapenem-resistant Acinetobacter baumannii (CRAB). In this study, a library of botanical extracts generated from plants used to treat infections in traditional medicine was screened for growth inhibition of CRAB. A crude extract of Schinus terebinthifolia leaves exhibited 80% inhibition at 256 µg/mL and underwent bioassay-guided fractionation, leading to the isolation of pentagalloyl glucose (PGG), a bioactive gallotannin. PGG inhibited growth of both CRAB and susceptible A. baumannii (MIC 64-256 µg/mL), and also exhibited activity against Pseudomonas aeruginosa (MIC 16 µg/mL) and Staphylococcus aureus (MIC 64 µg/mL). A mammalian cytotoxicity assay with human keratinocytes (HaCaTs) yielded an IC

Indexed as

Acinetobacter baumanniiAnacardiaceaeAnti-Bacterial Agentsbeta-Lactam ResistanceBiofilmsCarbapenemsDrug Evaluation, PreclinicalDrug Resistance, Multiple, BacterialHumansHydrolyzable TanninsKeratinocytesMagnetic Resonance SpectroscopyMicrobial Sensitivity TestsPlant ExtractsPseudomonas aeruginosaStaphylococcus aureusAnti-Bacterial AgentsCarbapenemsHydrolyzable TanninspentagalloylglucosePlant Extracts

Identifiers

PMID32948818
PMCPMC7501240
OpenAlexW3087044387

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.