ArticleCommunications biology2020
Flatfishes colonised freshwater environments by acquisition of various DHA biosynthetic pathways.
Article in Communications biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed.
- Glacier retreat shapes organic nutrient availability across lake succession.Science advances · 2026Article
- Nutritional adaptation in the marine to freshwater establishment process - how do diet and genotype shape phenotype?The Journal of experimental biology · 2026Article
- Biosynthesis of long-chain omega-3 fatty acids by the nestlings of a generalist seabird.The Journal of experimental biology · 2025Article
- Convergent Evolution and Predictability of Gene Copy Numbers Associated with Diets in Mammals.Genome biology and evolution · 2025Article
- High-resolution chromosome-level genome of Scylla paramamosain provides molecular insights into adaptive evolution in crabs.BMC biology · 2024Article
- Examination of gammarid transcriptomes reveals a widespread occurrence of key metabolic genes from epibiont bdelloid rotifers in freshwater species.Open biology · 2023Article
- Comparative Analyses of Scylla olivacea Gut Microbiota Composition and Function Suggest the Capacity for Polyunsaturated Fatty Acid Biosynthesis.Microbial ecology · 2023Article
- Diet effects on longevity, heat tolerance, lipid peroxidation and mitochondrial membrane potential in Daphnia.Oecologia · 2023Article
- A complete inventory of long-chain polyunsaturated fatty acid biosynthesis pathway enzymes in the miniaturized cyprinid Paedocypris micromegethes.Fish physiology and biochemistry · 2022Article
- Quantitative Lipidomics and Spatial MS-Imaging Uncovered Neurological and Systemic Lipid Metabolic Pathways Underlying Troglomorphic Adaptations in Cave-Dwelling Fish.Molecular biology and evolution · 2022Article
- Copy number variation of a fatty acid desaturase geneBiology letters · 2021Article
- Lack of ∆5 Desaturase Activity Impairs EPA and DHA Synthesis in Fish Cells from Red Sea Bream and Japanese Flounder.Marine biotechnology (New York, N.Y.) · 2021Article
- Influence of Dietary Lipids and Environmental Salinity on the n-3 Long-Chain Polyunsaturated Fatty Acids Biosynthesis Capacity of the Marine TeleostMarine drugs · 2021Article
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11 authors.
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Abstract
The colonisation of freshwater environments by marine fishes has historically been considered a result of adaptation to low osmolality. However, most marine fishes cannot synthesise the physiologically indispensable fatty acid, docosahexaenoic acid (DHA), due to incomplete DHA biosynthetic pathways, which must be adapted to survive in freshwater environments where DHA is poor relative to marine environments. By analysing DHA biosynthetic pathways of one marine and three freshwater-dependent species from the flatfish family Achiridae, we revealed that functions of fatty acid metabolising enzymes have uniquely and independently evolved by multi-functionalisation or neofunctionalisation in each freshwater species, such that every functional combination of the enzymes has converged to generate complete and functional DHA biosynthetic pathways. Our results demonstrate the elaborate patchwork of fatty acid metabolism and the importance of acquiring DHA biosynthetic function in order for fish to cross the nutritional barrier at the mouth of rivers and colonise freshwater environments.
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