Evidence map›Paper›PMID 32948795›Full record

ArticleScientific reports2020

Nitro-fatty acids suppress ischemic ventricular arrhythmias by preserving calcium homeostasis.

Martin Mollenhauer, Dennis Mehrkens, Anna Klinke, Max Lange, Lisa Remane, Kai Friedrichs, Simon Braumann, Simon Geißen, Sakine Simsekyilmaz, Felix S Nettersheim and 14 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Nitro Fatty Acids (NOMolecules (Basel, Switzerland) · 2021
    Review
  9. Nitro-Oleic Acid (NOInternational journal of molecular sciences · 2021
    Article
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 7 institutions in 2 countries.

Martin Mollenhauer *Clinic III for Internal Medicine, Department of Cardiology, Center for Molecular Medicine Cologne (CMMC), University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany. martin.mollenhauer@uk-koeln.de.
Dennis Mehrkens *Clinic III for Internal Medicine, Department of Cardiology, Center for Molecular Medicine Cologne (CMMC), University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.
Anna KlinkeClinic for General and Interventional Cardiology/ Angiology, Herz- Und Diabeteszentrum NRW, Ruhr-Universitaet Bochum, Bad Oeynhausen, Germany.
Max LangeClinic III for Internal Medicine, Department of Cardiology, Center for Molecular Medicine Cologne (CMMC), University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.
Lisa RemaneClinic III for Internal Medicine, Department of Cardiology, Center for Molecular Medicine Cologne (CMMC), University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.
Kai FriedrichsClinic for General and Interventional Cardiology/ Angiology, Herz- Und Diabeteszentrum NRW, Ruhr-Universitaet Bochum, Bad Oeynhausen, Germany.
Simon BraumannClinic III for Internal Medicine, Department of Cardiology, Center for Molecular Medicine Cologne (CMMC), University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.
Simon GeißenClinic III for Internal Medicine, Department of Cardiology, Center for Molecular Medicine Cologne (CMMC), University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.
Sakine SimsekyilmazClinic III for Internal Medicine, Department of Cardiology, Center for Molecular Medicine Cologne (CMMC), University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.
Felix S NettersheimClinic III for Internal Medicine, Department of Cardiology, Center for Molecular Medicine Cologne (CMMC), University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.
Samuel LeeClinic III for Internal Medicine, Department of Cardiology, Center for Molecular Medicine Cologne (CMMC), University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.
Gabriel PeinkoferClinic III for Internal Medicine, Department of Cardiology, Center for Molecular Medicine Cologne (CMMC), University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.
Anne C GeislerGeneral and Interventional Cardiology University Heart Center Hamburg, University Hospital Hamburg-Eppendorf (UKE), Hamburg, Germany.
Bianca GeisGeneral and Interventional Cardiology University Heart Center Hamburg, University Hospital Hamburg-Eppendorf (UKE), Hamburg, Germany.
Alexander P SchwoererDepartment of Cellular and Integrative Physiology, University Medical Center Hamburg Eppendorf, DZHK (German Centre of Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany.
Lucie CarrierExperimental Pharmacology and Toxicology, University Hospital Hamburg-Eppendorf (UKE), Hamburg, Germany.
Bruce A FreemanDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA.
Matthias DewenterInstitute of Experimental Cardiology, University of Heidelberg, Heidelberg, Germany.
Xiaojing LuoDepartment of Pharmacology and Toxicology, Technische Universitaet Dresden, Dresden, Germany.
Ali El-ArmoucheDepartment of Pharmacology and Toxicology, Technische Universitaet Dresden, Dresden, Germany.
Michael WagnerDepartment of Pharmacology and Toxicology, Technische Universitaet Dresden, Dresden, Germany.
Matti AdamClinic III for Internal Medicine, Department of Cardiology, Center for Molecular Medicine Cologne (CMMC), University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.
Stephan BaldusClinic III for Internal Medicine, Department of Cardiology, Center for Molecular Medicine Cologne (CMMC), University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.
Volker RudolphClinic for General and Interventional Cardiology/ Angiology, Herz- Und Diabeteszentrum NRW, Ruhr-Universitaet Bochum, Bad Oeynhausen, Germany.
University of Cologne · DEHeart and Diabetes Center North Rhine-Westphalia · DETechnische Universität Dresden · DEGerman Centre for Cardiovascular Research · DEUniversity Medical Center Hamburg-Eppendorf · DEUniversität Hamburg · DEUniversity of Pittsburgh · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nitro-fatty acids are electrophilic anti-inflammatory mediators which are generated during myocardial ischemic injury. Whether these species exert anti-arrhythmic effects in the acute phase of myocardial ischemia has not been investigated so far. Herein, we demonstrate that pretreatment of mice with 9- and 10-nitro-octadec-9-enoic acid (nitro-oleic acid, NO

Indexed as

AnimalsAnti-Arrhythmia AgentsArrhythmias, CardiacCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2CatecholaminesDietary SupplementsHomeostasisIsoproterenolMaleMice, Inbred StrainsMyocardial IschemiaMyocytes, CardiacNitro CompoundsOleic AcidsPhosphorylationAnti-Arrhythmia AgentsCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2CatecholaminesCXA-10IsoproterenolNitro CompoundsOleic Acidsryanodine receptor 2. mouseRyanodine Receptor Calcium Release Channel

Identifiers

PMID32948795
PMCPMC7501300
OpenAlexW3087204693

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.