ArticleScientific reports2020
Azobenzene-based sinusoidal surface topography drives focal adhesion confinement and guides collective migration of epithelial cells.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Photomechanical Azopolymers and Digital Polarization Optics: A Versatile Platform for Surface Microstructure Fabrication.ACS applied optical materials · 2025Review
- Cellular Signaling at the Nano-Bio Interface: Spotlighting Membrane Curvature.Annual review of physical chemistry · 2025Review
- A biodegradable microgrooved and tissue mechanocompatible citrate-based scaffold improves bladder tissue regeneration.Bioactive materials · 2024Article
- Turn-on protein switches for controlling actin binding in cells.Nature communications · 2024Article
- Strategies to control humidity sensitivity of azobenzene isomerisation kinetics in polymer thin films.Communications materials · 2024Article
- Light-Induced Nanoscale Deformation in Azobenzene Thin Film Triggers Rapid Intracellular CaAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Turn-On Protein Switches for Controlling Actin Binding in Cells.bioRxiv : the preprint server for biology · 2023Article
- Electrochemiluminescence Imaging of Cellular Contact Guidance on Microfabricated Substrates.Chemical & biomedical imaging · 2023Article
- Accelerated epithelial layer healing induced by tactile anisotropy in surface topography.Science advances · 2023Article
- Prospects and Challenges of Electrospun Cell and Drug Delivery Vehicles to Correct Urethral Stricture.International journal of molecular sciences · 2022Review
- Insight and Recent Advances into the Role of Topography on the Cell Differentiation and Proliferation on Biopolymeric Surfaces.International journal of molecular sciences · 2022Review
- Profiling the responsiveness of focal adhesions of human cardiomyocytes to extracellular dynamic nano-topography.Bioactive materials · 2022Article
- Light-Responsive Bilayer Cell Culture Platform for Reversible Cell Guidance.Small science · 2022Article
- Recapitulating dynamic ECM ligand presentation at biomaterial interfaces: Molecular strategies and biomedical prospects.Exploration (Beijing, China) · 2022Review
- Cooperation between myofibril growth and costamere maturation in human cardiomyocytes.Frontiers in bioengineering and biotechnology · 2022Article
- Patterning ECM microstructure to investigate 3D cellular dynamics under multiplexed mechanochemical guidance.F1000Research · 2022Article
- A switchable light-responsive azopolymer conjugating protein micropatterns with topography for mechanobiological studies.Frontiers in bioengineering and biotechnology · 2022Article
- Tight Junction ZO Proteins Maintain Tissue Fluidity, Ensuring Efficient Collective Cell Migration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Nano-Second Laser Interference Photoembossed Microstructures for Enhanced Cell Alignment.Polymers · 2021Article
- Multiscale Hierarchical Surface Patterns by Coupling Optical Patterning and Thermal Shrinkage.ACS applied materials & interfaces · 2021Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Surface topography is a key parameter in regulating the morphology and behavior of single cells. At multicellular level, coordinated cell displacements drive many biological events such as embryonic morphogenesis. However, the effect of surface topography on collective migration of epithelium has not been studied in detail. Mastering the connection between surface features and collective cellular behaviour is highly important for novel approaches in tissue engineering and repair. Herein, we used photopatterned microtopographies on azobenzene-containing materials and showed that smooth topographical cues with proper period and orientation can efficiently orchestrate cell alignment in growing epithelium. Furthermore, the experimental system allowed us to investigate how the orientation of the topographical features can alter the speed of wound closure in vitro. Our findings indicate that the extracellular microenvironment topography coordinates their focal adhesion distribution and alignment. These topographic cues are able to guide the collective migration of multicellular systems, even when cell-cell junctions are disrupted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.