ArticleNature communications2020
Semiconductor photocatalysis to engineering deuterated N-alkyl pharmaceuticals enabled by synergistic activation of water and alkanols.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 84 citations in OpenAlex.
- Alternating Current-Driven Hydrogen Isotope Labeling of Aliphatic Amines Using 1,3-Propanedithiol as an Efficient Hydrogen Atom Transfer Reagent.Journal of the American Chemical Society · 2026Article
- Electricity-driven site-selective deuteration of pharmaceuticals.Chemical science · 2026Article
- Installation of d3-methyl group to drugs by continuous-flow solid-phase synthesis.Nature communications · 2025Article
- Homologous heteropolyaromatic covalent organic frameworks for enhancing photocatalytic hydrogen peroxide production and aerobic oxidation.Nature communications · 2025Article
- Electroreductive amination of carboxylic acids by cobalt catalysis.Nature communications · 2025Article
- Construction of axially chiral molecules enabled by photoinduced enantioselective reactions.Chemical science · 2024Review
- Modulation of Electronic Availability in g-CMolecules (Basel, Switzerland) · 2024Article
- A Recyclable Inorganic Lanthanide Cluster Catalyst for Chemoselective Aerobic Oxidation of Thiols.Molecules (Basel, Switzerland) · 2024Article
- Heterogeneous Organocatalysts for Light-Driven Reactions in Continuous Flow.Molecules (Basel, Switzerland) · 2024Review
- Transition-metal-free silylboronate-mediated cross-couplings of organic fluorides with amines.Nature communications · 2023Article
- One-pot H/D exchange and low-coordinated iron electrocatalyzed deuteration of nitriles in DNature communications · 2022Article
- Electrocatalytic hydrogenation of quinolines with water over a fluorine-modified cobalt catalyst.Nature communications · 2022Article
- Photocatalytic dehydrogenative C-C coupling of acetonitrile to succinonitrile.Nature communications · 2022Article
- Sodium alkoxide-mediated g-CRSC advances · 2022Article
- Synthesis, solid state self-assembly driven by antiparallel π⋯π stacking and {⋯H-C-C-F}RSC advances · 2022Article
- Copper-catalysed low-temperature water-gas shift reaction for selective deuteration of aryl halides.Chemical science · 2021Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Precisely controlled deuterium labeling at specific sites of N-alkyl drugs is crucial in drug-development as over 50% of the top-selling drugs contain N-alkyl groups, in which it is very challenging to selectively replace protons with deuterium atoms. With the goal of achieving controllable isotope-labeling in N-alkylated amines, we herein rationally design photocatalytic water-splitting to furnish [H] or [D] and isotope alkanol-oxidation by photoexcited electron-hole pairs on a polymeric semiconductor. The controlled installation of N-CH
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