Evidence map›Paper›PMID 32948758›Full record

ArticleNature communications2020

Integration of absolute multi-omics reveals dynamic protein-to-RNA ratios and metabolic interplay within mixed-domain microbiomes.

F Delogu, B J Kunath, P N Evans, M Ø Arntzen, T R Hvidsten, P B Pope

Abstract read
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
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  9. Article
  10. Integrative meta-omics in Galaxy and beyond.Environmental microbiome · 2023
    Article
  11. Review
  12. Article
  13. Long-Read Metagenomics and CAZyme Discovery.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

F DeloguFaculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Ås, N-1432, Norway. fra.delogu92@gmail.com.ORCID http://orcid.org/0000-0002-7211-8011
B J KunathFaculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Ås, N-1432, Norway.ORCID http://orcid.org/0000-0002-3356-8562
P N EvansAustralian Centre for Ecogenomics, School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, QLD, Australia.
M Ø ArntzenFaculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Ås, N-1432, Norway.ORCID http://orcid.org/0000-0002-1803-727X
T R HvidstenFaculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Ås, N-1432, Norway.ORCID http://orcid.org/0000-0001-6097-2539
P B PopeFaculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Ås, N-1432, Norway. phil.pope@nmbu.no.ORCID http://orcid.org/0000-0002-2067-4059

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While the field of microbiology has adapted to the study of complex microbiomes via modern meta-omics techniques, we have not updated our basic knowledge regarding the quantitative levels of DNA, RNA and protein molecules within a microbial cell, which ultimately control cellular function. Here we report the temporal measurements of absolute RNA and protein levels per gene within a mixed bacterial-archaeal consortium. Our analysis of this data reveals an absolute protein-to-RNA ratio of 10

Indexed as

ArchaeaBacteriaDNAGene Expression ProfilingGenome, MicrobialHumansMetabolomicsMicrobiotaPhenotypeProteinsProteomeProteomicsRNATranscriptomeYeastsDNAProteinsProteomeRNA

Identifiers

PMID32948758
PMCPMC7501288

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.