ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020
Dopaminergic Modulation of Human Intertemporal Choice: A Diffusion Model Analysis Using the D2-Receptor Antagonist Haloperidol.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Differential Associations of Dopamine and Serotonin With Reward and Punishment Processes in Humans: A Systematic Review and Meta-Analysis.JAMA psychiatry · 2025Pooled it
- Dopamine and Temporal Discounting: Revisiting Pharmacology and Individual Differences.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Trial
- The catecholamine precursor Tyrosine reduces autonomic arousal and decreases decision thresholds in reinforcement learning and temporal discounting.PLoS computational biology · 2022Trial
- Trial
- Cognitive and Emotional Predictors of Decision-Making in Adults: Roles of Cognitive Functions and Emotion Regulation Difficulties.Europe's journal of psychology · 2026Article
- Genome-wide association study of delay discounting identifies 11 loci and reveals transdiagnostic associations across mental and physical health.Molecular psychiatry · 2026Article
- Association of Menstrual Cycle with Fronto-Striatal Connectivity and Delay Discounting.Behavioral sciences (Basel, Switzerland) · 2025Article
- Balancing Risk and Reward: Dopamine's Central Role in Economic Decision-Making.Brain sciences · 2025Review
- Non-decision time: The Higgs Boson of decision.Psychological review · 2025Article
- Phenylketonuria as an Adherence Disease.Patient preference and adherence · 2025Review
- Cross-species translational paradigms for assessing positive valence system as defined by the RDoC matrix.Journal of neurochemistry · 2025Review
- Neural reward system reflects individual value comparison strategy in cost-benefit decisions.Communications biology · 2024Article
- Dopamine and acetylcholine have distinct roles in delay- and effort-based decision-making in humans.PLoS biology · 2024Article
- Article
- Decomposition of Reinforcement Learning Deficits in Disordered Gambling via Drift Diffusion Modeling and Functional Magnetic Resonance Imaging.Computational psychiatry (Cambridge, Mass.) · 2024Article
- Dopamine Alters the Effect of Brain Stimulation on Decision-Making.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Dopamine regulates decision thresholds in human reinforcement learning in males.Nature communications · 2023Article
- Pharmacological Modulation of Temporal Discounting: A Systematic Review.Healthcare (Basel, Switzerland) · 2023Review
- Toward a Unifying Account of Dopamine's Role in Cost-Benefit Decision Making.Biological psychiatry global open science · 2023Review
- Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The neurotransmitter dopamine is implicated in diverse functions, including reward processing, reinforcement learning, and cognitive control. The tendency to discount future rewards over time has long been discussed in the context of potential dopaminergic modulation. Here we examined the effect of a single dose of the D2 receptor antagonist haloperidol (2 mg) on temporal discounting in healthy female and male human participants. Our approach extends previous pharmacological studies in two ways. First, we applied combined temporal discounting drift diffusion models to examine choice dynamics. Second, we examined dopaminergic modulation of reward magnitude effects on temporal discounting. Hierarchical Bayesian parameter estimation revealed that the data were best accounted for by a temporal discounting drift diffusion model with nonlinear trialwise drift rate scaling. This model showed good parameter recovery, and posterior predictive checks revealed that it accurately reproduced the relationship between decision conflict and response times in individual participants. We observed reduced temporal discounting and substantially faster nondecision times under haloperidol compared with placebo. Discounting was steeper for low versus high reward magnitudes, but this effect was largely unaffected by haloperidol. Results were corroborated by model-free analyses and modeling via more standard approaches. We previously reported elevated caudate activation under haloperidol in this sample of participants, supporting the idea that haloperidol elevated dopamine neurotransmission (e.g., by blocking inhibitory feedback via presynaptic D2 auto-receptors). The present results reveal that this is associated with an augmentation of both lower-level (nondecision time) and higher-level (temporal discounting) components of the decision process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.