Evidence map›Paper›PMID 32948653›Full record

ArticleJournal for immunotherapy of cancer2020

Differential gene expression of tumor-infiltrating CD8

Reem Saleh, Varun Sasidharan Nair, Salman M Toor, Rowaida Z Taha, Khaled Murshed, Mahmood Al-Dhaheri, Mahwish Khawar, Mahir Abdulla Petkar, Mohamed Abu Nada, Fares Al-Ejeh and 1 more

Open access · goldAbstract read
In one paragraph

Article in Journal for immunotherapy of cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
1.8field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
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  6. Review
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  8. Article
  9. Machine learning-based model for CD4Scientific reports · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Reem SalehCancer Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation (QF), Doha, Qatar.
Varun Sasidharan NairCancer Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation (QF), Doha, Qatar.
Salman M ToorCancer Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation (QF), Doha, Qatar.
Rowaida Z TahaCancer Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation (QF), Doha, Qatar.
Khaled MurshedDepartment of Pathology, Hamad Medical Corporation, Doha, Qatar.
Mahmood Al-DhaheriDepartment of Surgery, Hamad Medical Corporation, Doha, Qatar.
Mahwish KhawarDepartment of Surgery, Hamad Medical Corporation, Doha, Qatar.
Mahir Abdulla PetkarDepartment of Pathology, Hamad Medical Corporation, Doha, Qatar.
Mohamed Abu NadaDepartment of Surgery, Hamad Medical Corporation, Doha, Qatar.
Fares Al-EjehCancer Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation (QF), Doha, Qatar.ORCID 0000-0002-1553-0077
Eyad ElkordCancer Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation (QF), Doha, Qatar eelkord@hbku.edu.qa.ORCID 0000-0002-3868-0318
Hamad bin Khalifa University · QAHamad Medical Corporation · QA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCytotoxic CD8

methodsUsing RNA-Seq, transcriptomes of sorted CD3

resultsGenes related to epigenetic regulation and response to hypoxia were upregulated in CD8

conclusionsOur data provided insights into the altered regulation of biological mechanisms and signaling pathways in CD8

Indexed as

AdultAgedCD8-Positive T-LymphocytesColorectal NeoplasmsFemaleGene ExpressionHumansLymphocytes, Tumor-InfiltratingMaleMiddle AgedPrognosisYoung Adultadaptive immunityCD8-positive T-lymphocytesgene expression profilinglymphocytestumor-infiltratingtumor microenvironment

Identifiers

PMID32948653
PMCPMC7511623
OpenAlexW3087682776

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.