ArticleNeurology(R) neuroimmunology & neuroinflammation2020
Free light chains kappa can differentiate between myelitis and noninflammatory myelopathy.
Article in Neurology(R) neuroimmunology & neuroinflammation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A systematic review and meta-analysis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2023Pooled it
- Intrathecal immunoglobulin production in the diagnosis, prognosis, and monitoring of autoimmune diseases of the central nervous system.Journal of translational autoimmunity · 2026Review
- KFLC to Total CSF Protein Ratio Is an Alternative to KFLC Index to Diagnose Multiple Sclerosis: A Retrospective Study of 814 Cases.Neurology(R) neuroimmunology & neuroinflammation · 2025Article
- Genetic Architecture and Functional Implications of the CSF-Contacting Nucleus.Neuroscience bulletin · 2023Article
- The role of intrathecal free light chains kappa for the detection of autoimmune encephalitis in subacute onset neuropsychiatric syndromes.Scientific reports · 2023Article
- Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A consensus statement.Multiple sclerosis (Houndmills, Basingstoke, England) · 2023Article
- Kappa Free Light Chain Biomarkers Are Efficient for the Diagnosis of Multiple Sclerosis: A Large Multicenter Cohort Study.Neurology(R) neuroimmunology & neuroinflammation · 2023Article
- Biomarkers in autoimmune diseases of the central nervous system.Frontiers in immunology · 2023Review
- Establishing the best combination of the kappa free light chain index and oligoclonal bands for an accurate diagnosis of multiple sclerosis.Frontiers in immunology · 2023Article
- A New Laboratory Workflow Integrating the Free Light Chains Kappa Quotient into Routine CSF Analysis.Biomolecules · 2022Article
- Evidence for an Intrathecal Immunoglobulin Synthesis by Kappa Free Light Chains in Neurological Patients with an Isolated Band in Isoelectric Focusing.Biomedicines · 2022Article
- Diagnostic Cerebrospinal Fluid Biomarker in Early and Late Onset Multiple Sclerosis.Biomedicines · 2022Article
- Kappa Free Light Chains in Cerebrospinal Fluid in Inflammatory and Non-Inflammatory Neurological Diseases.Brain sciences · 2022Article
- Kappa Free Light Chains, Soluble Interleukin-2 Receptor, and Interleukin-6 Help Explore Patients Presenting With Brain White Matter Hyperintensities.Frontiers in immunology · 2022Article
- High Levels of Cerebrospinal Fluid Kappa Free Light Chains Relate to IgM Intrathecal Synthesis and Might Have Prognostic Implications in Relapsing Multiple Sclerosis.Frontiers in immunology · 2022Observational
- Review
- The Influence of Renal Function Impairment on Kappa Free Light Chains in Cerebrospinal Fluid.Journal of central nervous system disease · 2021Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo test the hypothesis that the intrathecal synthesis of free light chain kappa (FLC-k) can be used as a CSF biomarker to differentiate patients with myelitis due to multiple sclerosis (MS), myelitis due to neuromyelitis optica spectrum disease (NMOSD), and noninflammatory myelopathy, we analyzed FLC-k in 26 patients with MS myelitis, 9 patients with NMOSD myelitis, and 14 patients with myelopathy.
methodsThis is a retrospective monocentric cohort study. FLC-k were analyzed using the nephelometric Siemens FLC-k kit in paired samples of CSF and sera. Intrathecal fraction (IF) of FLC-k was plotted in a FLC-k quotient diagram.
resultsNinety-six percent of patients with MS myelitis had an intrathecal synthesis of FLC-k in comparison with 55.6% for NMOSD and 14.3% of patients with noninflammatory myelopathy. The locally synthesized absolute amount of FLC-k was significantly higher in patients with myelitis due to MS than in patients with NMOSD (
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