Evidence map›Paper›PMID 32948514›Full record

Trial reportArchives of disease in childhood2021

Self-administration of adrenaline for anaphylaxis during in-hospital food challenges improves health-related quality of life.

Sarah Burrell, Nandinee Patel, Marta Vazquez-Ortiz, Dianne E Campbell, Audrey DunnGalvin, Paul J Turner

Registry-linked trialOpen access · hybridAbstract readClinical Trial, Phase IIRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Archives of disease in childhood, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02149719 (Phase 2 Randomised Study of Oral Immunotherapy Using Boiled Peanut to Induce Desensitisation in Children With Challenge-proven, IgE-mediated Peanut Allergy), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02149719 nacompletednot on this map

Phase 2 Randomised Study of Oral Immunotherapy Using Boiled Peanut to Induce Desensitisation in Children With Challenge-proven, IgE-mediated Peanut Allergy

TypeinterventionalSponsorImperial College LondonRan2015 to 2022Enrolled47ConditionsIgE Mediated Peanut AllergyArmsDesensitisation using boiled peanut, Desensitisation using boiled peanut (deferred start)
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Who Needs Epinephrine? Anaphylaxis, Autoinjectors, and Parachutes.The journal of allergy and clinical immunology. In practice · 2023
    Review
  5. Will Oral Food Challenges Still Be Part of Allergy Care in 10 Years' Time?The journal of allergy and clinical immunology. In practice · 2023
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 4 countries.

Sarah BurrellSection of Inflammation, Repair and Development, National Heart & Lung Institute, Imperial College London, London, UK.
Nandinee PatelSection of Inflammation, Repair and Development, National Heart & Lung Institute, Imperial College London, London, UK.
Marta Vazquez-OrtizSection of Inflammation, Repair and Development, National Heart & Lung Institute, Imperial College London, London, UK.
Dianne E CampbellDiscipline of Child and Adolescent Health, University of Sydney, Sydney, New South Wales, Australia.
Audrey DunnGalvinSchool of Applied Psychology, Department of Paediatrics and Child Health, University College Cork, Cork, Ireland.
Paul J TurnerSection of Inflammation, Repair and Development, National Heart & Lung Institute, Imperial College London, London, UK p.turner@imperial.ac.uk.ORCID 0000-0001-9862-5161
Imperial College London · GBThe University of Sydney · AUUniversity College Cork · IE

Funding

Medical Research Council MR/K010468/1
6 · The paper itself

Abstract

objectiveTo assess the impact of anaphylaxis on health-related quality of life (HRQL) and self-efficacy in food-allergic patients undergoing in-hospital food challenge.

designSecondary analysis of a randomised controlled trial.

settingSpecialist allergy centre. PATIENTS: Peanut-allergic young people aged 8-16 years.

interventionsDouble-blind, placebo-controlled food challenge to peanut, with HRQL and self-efficacy assessed using validated questionnaire, approximately 2 weeks prior to and 2 weeks after challenge. Where possible, anaphylaxis was treated with self-injected adrenaline (epinephrine).

main outcome measuresChange in HRQL and self-efficacy.

results56 participants had reactions at food challenge, of whom 16 (29%) had anaphylaxis. Overall, there was an improvement in HRQL (mean 2.6 points (95% CI 0.3 to 4.8); p=0.030) and self-efficacy (mean 4.1 points (95% CI 2.4 to 5.9); p<0.0001), independent of whether anaphylaxis occurred. Parents also reported improved HRQL (mean 10.3 points (95% CI 5.9 to 14.7); p<0.0001). We found evidence of discordance between the improvement in HRQL and self-efficacy as reported by young people and that perceived by parents in their child.

conclusionsAnaphylaxis at food challenge, followed by self-administration of injected adrenaline, was associated with an increase in HRQL and self-efficacy in young people with peanut allergy. We found no evidence that the occurrence of anaphylaxis had a detrimental effect. Young people should be encouraged to self-administer adrenaline using their autoinjector device to treat anaphylaxis at in-hospital challenge. TRIAL REGISTRATION NUMBER: NCT02149719.

Indexed as

Administration, OralAdolescentAllergensAnaphylaxisArachisChildCross-Over StudiesDesensitization, ImmunologicDouble-Blind MethodEpinephrineFemaleHospitalsHumansInjections, IntramuscularMaleNutsAllergensEpinephrineadolescent healththerapeutics

Identifiers

PMID32948514
PMCPMC8142442
OpenAlexW3087415319

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.